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Carcinogenicity May cause cancer. <br /> IARC Monographs.Overall Evaluation of Carcinogenicity <br /> Benzene(CAS 71-43-2) 1 Carcinogenic to humans. <br /> Cumene(CAS 98-82-8) 2B Possibly carcinogenic to humans. <br /> Ethylbenzene(CAS 100-41-4) 2B Possibly carcinogenic to humans. <br /> Gasoline(CAS 86290-81-5) 2B Possibly carcinogenic to humans. <br /> Toluene(CAS 108-88-3) 3 Not classifiable as to carcinogenicity to humans. <br /> Xylene(o, m, p isomers)(CAS 1330-20-7) 3 Not classifiable as to carcinogenicity to humans. <br /> NTP Report on Carcinogens <br /> Benzene(CAS 71-43-2) Known To Be Human Carcinogen. <br /> US.OSHA Specifically Regulated Substances(29 CFR 1910.1001-1050) <br /> Benzene(CAS 71-43-2) Cancer <br /> Reproductive toxicity Suspected of damaging fertility or the unborn child. <br /> Benzene,xylene and toluene have demonstrated animal effects of reproductive toxicity. Animal <br /> studies of benzene have shown testicular effects, alterations in reproductive cycles,chromosomal <br /> aberrations and embryo/fetotoxicity. Ethanol has demonstrated human effects of reproductive <br /> toxicity. Can cause adverse reproductive effects-such as birth defects, miscarriages, or infertility. <br /> Avoid exposure to women during early pregnancy.Avoid contact during pregnancy/while nursing. <br /> Specific target organ toxicity- May cause drowsiness or dizziness. <br /> single exposure <br /> Specific target organ toxicity- May cause damage to the following organs through prolonged or repeated exposure: Blood. <br /> repeated exposure Kidneys. Liver. <br /> Aspiration hazard May be fatal if swallowed and enters airways. <br /> Chronic effects Repeated exposure of laboratory animals to high concentrations of gasoline vapors has caused <br /> kidney damage and cancer in rats and cancer in mice. Gasoline was evaluated for genetic activity <br /> in assays using microbial cells,cultured mammalian cells and rat bone marrow cells. The results <br /> were all negative so gasoline was considered nonmutagenic under these conditions. <br /> Overexposure to this product or its components has been suggested as a cause of liver <br /> abnormalities in laboratory animals and humans. Lifetime studies by the American Petroleum <br /> Institute have shown that kidney damage and kidney cancer can occur in male rats after prolonged <br /> inhalation exposures at elevated concentrations of total gasoline. Kidneys of mice and female rats <br /> were unaffected. The U.S. EPA Risk Assessment Forum has concluded that the male rat kidney <br /> tumor results are not relevant for humans.Total gasoline exposure also produced liver tumors in <br /> female mice only.The implication of these data for humans has not been determined. <br /> Further information Symptoms may be delayed. <br /> 12. Ecological information <br /> Ecotoxicity Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. <br /> Components Species Test Results <br /> 1,2,4,Trimethylbenzene(CAS 95-63-6) <br /> Aquatic <br /> Fish LC50 Fathead minnow(Pimephales promelas) 7.19-8.28 mg/l, 96 hours <br /> Benzene(CAS 71-43-2) <br /> Aquatic <br /> Crustacea EC50 Water flea(Daphnia magna) 8.76- 15.6 mg/I,48 hours <br /> Fish LC50 Rainbow trout,donaldson trout 7.2- 11.7 mg/I,96 hours <br /> (Oncorhynchus mykiss) <br /> Cumene(CAS 98-82-8) <br /> Aquatic <br /> Crustacea EC50 Brine shrimp(Artemia sp.) 3.55-11.29 mg/l,48 hours <br /> Fish LC50 Rainbow trout,donaldson trout 2.7 mg/l,96 hours <br /> (Oncorhynchus mykiss) <br /> Cyclohexane(CAS 110-82-7) <br /> Aquatic <br /> Fish LC50 Fathead minnow(Pimephales promelas) 3.961 -5.181 mg/l,96 hours <br /> Striped bass(Morone saxatilis) 8.3 mg/l,96 hours <br /> UNLEADED GASOLINE <br /> 913457 Version#:03 Revison date:23-May-2014 Print date:23-May-2014 10/15 <br /> Prepared by 3E Company <br />