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No 316 Benzene 8/%
<br /> Setiorl<61-HOW[`Ha mi rd Dam
<br /> Carcinogenicity I ticlist benzene as,respectively,a;uperiia imam carcinogen,a cancerazar and,bas7-Qon
<br /> sufficient human and animal evidence,a human carcinogen(Group 1)
<br /> Summary of Risks Prolonged skin contact or excessive inhalation of benzene vapor may cause headache,weakness.appetite loss,and fatigue
<br /> I
<br /> important health hazards are cancer(leukemia)and bone marrow damage with injury to blood-forming tissue from chronic low-level
<br /> sure.Higher level exposures may irritate the respiratory tract and cause central nervous system(CNS)depression
<br /> edictal Conditions Aggravated by Long-Term Exposure:Exposure may worsen ailments of the heart,lungs,liver,kidneys,blood,and CNS
<br /> Target Orrggaans.Blood,central nervous system,bone marrow,eyes,upper respiratory tract,and skin
<br /> Primary entry Routes.Inhalation,skin contact.
<br /> Acute Effects.Symptoms of acute overexposure Include untauan of the eyes,nose,and respiratory tract,breathlessness,euphoria,nausea,
<br /> drowsiness,headache,dizziness,and intoxication Severe exposure may lead to convulsions and unconsciousness Skin contact may cause a
<br /> drying rash(dermatitis)
<br /> Chronic Effects:Long-term chronic exposure may result in many blood disorders ranging from aplastic anemia(an inability to form blood cells)
<br /> to leukenua.
<br /> FIRST AID
<br /> Eyes:Gently lift the eyelids and flush immediately arid continuously with flooding amounts of water until transported to an emergency medical
<br /> facility Consult a physician immediately
<br /> Skin:Quickly remove contaminated clothing Immediately rinse with flooding amounts of water for at least 15 min For reddened or blistered
<br /> skirl,consult a physician Wash affected area with soap and water
<br /> Inhalation:Remove exposed person to fresh air Emergency personnel should protect against Inhalation exposure Provide CPR to support
<br /> breathing or circulation as necessary Keep awake and transport to a medical facility
<br /> Ingestloa.Never give anythiig by mouth to an unconscious or convulsing person. f ingested,do not Induce vomiting since aspiration may be
<br /> falai.Call a physician unmediatelyy
<br /> Arter first aid,get apppropriate In-plant,para=medic,or community medical support.
<br /> Physician's Note:Evaluate chronic exposure with a CBC,peripheral smear,and reticulocyte count for signs of myelotoxicity Follow up any
<br /> early indicators of leukemia with a bone marrow biopsy Urinary phenol conjugates may be used for biological momtonng of recent exposure
<br /> Acute management is primarily supportive for CNS depression
<br /> Section 7. .Procedu>rt s
<br /> SpUVUak:Design and practice a benzenespill control and countermeasure plan(SCOP) Notify safety personnel,evacuate all unnecessary
<br /> personnel,eliminate all heat and ignition sources,and provide adequate ventilation Cleanup personnel should protect against vapor inhaIanon.eye
<br /> contact,and skin absorption Absorb as much benzene as possible with an inert,noncombustible material For large spills,dike far ahead of spill
<br /> and contain liquid.Use nonsparking tools to place waste liquid or absorbent into closable container;for disposal Keep waste out of confined
<br /> spaces such as sewers,watersheds,and waterways because of explosion danger Follow applicable OSHA regulations(29 CFR 1910 120)
<br /> Disposal:Contact your supplier or a licensed contractor for detailed recommendations Follow applicable Federal,state,and local regulations
<br /> EPA Designations
<br /> Listed as a RCRA Hazardous Waste(40 CFR 261.331 Hazardous Waste No U019
<br /> L ted as a CERCLA Hazardous Substance*(40 CFR 302 4),Reportable Quantity(RQ) 1000 lb(454 kg)[*per Clean Water Act,Sec 307(a),
<br /> 1 (b)(4X 112,and per RCRA,Sec 30011
<br /> A Extremely Hazardous Substance(40 CFR 355) Not listed
<br /> Listed as SARA Toxic Chemical(40 CER 372 65)
<br /> OSHA Designations
<br /> Listed as an Air Contaminant(29 CFR 19101000,Tables Z-1-A and Z-2)
<br /> �ti'�ti011i�. S �.P�I'� ibiti Dtdt$. ti
<br /> Goggles.Wear protective eyeglasses or chemical safety goggles,per OSHA eye-and face-protection regulations(29 CFR 19I0 . ` A
<br /> Respirator:Seek professional advice prior to respirator selection and use Follow OSHA respirator regulations(29 CFR 1910 134)and,if neces-
<br /> sary,wear a NIOSH-approved respirator For emergency or nonroutine operations(cleaning spills,reactor vessels,or storage tanks),wear an
<br /> SCBA.Warning Air-purifying respirators do not protect workers in oxygen-deficient atmospheres
<br /> Other:Wear impervious gloves,boots,aprons,and gauntlets to prevent skin contact
<br /> Ventilation:Provide general and local explosion-proof ventilation systems to maintain airborne concentrations at least below the OSHA PELs
<br /> (Sec 2) Local exhaust venulation is preferred since it prevents contaminant dispersion into the work area by controlling it at its source(103)
<br /> Safety Stations-Make available in the work area emergency eyewash stations,safety/quick-drench showers,and washing facilities
<br /> Contaminated Equipment:Never wear contact lenses in the work area soft lenses may absorb,and all lenses concentrate,intants Remove this
<br /> material from your shoes and equipment.Launder contaminated clothing before wearing
<br /> Comments:Never eat,drunk,or smoke in work areas Practice good personal hygiene after using this material,especially before eating.drinking,
<br /> smoking.usingthe toilet,or WIXM&cosmetics
<br /> sett t S pea-at Premutieft ilod comiunts n v ry kM
<br /> Storage Requirements.Store in tightly closed containers in a cool,dry,well-ventilated area away from all heat and Ignition sources and
<br /> incompatible materials Caution!Benzene vapor may form explosive mixtures in air To prevent static sparks,electrically ground and bond all
<br /> containers and equipment used in shipping,receiving,or transferring operations m production and storage areas When opening or closing
<br /> benzene containers,use nonsparking tools Keep fire extinguishers readily available
<br /> Engineering Controls:Because OSHA specifically regulates benzene(29 CFR 19101028).educate workers about its potential hazards and
<br /> dangers Minimize all possible exposures to carcinogens If possible,substitute less toxic solvents for benzene,use flus material with extreme
<br /> caution and only of absolutely essential.Avoid vapor inhalation and skit and eye contact.Use only with adequate ventilation and appropriate
<br /> personal protective gear Institute a respiratory protection program that mcludes regular training,maintenance,inspection.and evaluation
<br /> Designate regulated areas of benzene use(see legend in the box below)and label benzene containers with"DANGER,CONTAINS BENZENE,
<br /> CANCER HAZARD"
<br /> Other Precautions:Provide preplacement and periodic medical examinations with emphasis on a history of blood disease or previous exposure
<br /> Transportation Data(49 CFR 172.101,.102)
<br /> T Shipping Name:Benzene(benzol) IMO Shipping Name:Benzene DANGER
<br /> W.o
<br /> Hazard Class: IN
<br /> Flammable liquid IMO Hazard Class:3 2 BENZENE
<br /> :UNI 114 ID No..UNI 114 CANCER HAZARD
<br /> DOT Label.Flammable liquid IMO Label- Flammable liquid FLAMMABLE—NO SMOKING
<br /> DOT Packaging Exceptions. 173 118 IMDG Packaging Group H AUTHORIZED PERSONNEL ONLY
<br /> DOT Packaging Requirements: 173 119 RESPIRA'T'OR REQUIRED
<br /> MSOS conisation References 1,2, 12,26.73.94-94,100.101. 103.109,124,126,127,132,134,136,138,139,143
<br /> Prepared by MI Allison,BS,Industrial Hygiene Review DJ Wilson.CIH,Medical Review MJ Upfal,MD,MPH,Edited by JR Stuart,MS
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