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No 318 Xylene(Mixed Isomers) 9192
<br /> Section 6. Health Hazard Data continued
<br /> uregulanty was reported in association with workplace exposure to xylene perhaps due to effects on liver metabolism Xylene crosses the human
<br /> placenta,but does not appear to be teratogenic under conditions tested to date Medical Conditions Aggravated by Long-Term Exposure CNS
<br /> respiratory,eye,skit,gastrointestinal(GI),liver and kidney disorders Target Organs CNS,eyes,GI tract,liver,kidneys,and skin Primary
<br /> ry Routes Inhalation,skit absorption(slight),eye contact,ingestion Acute Effects.Inhalation of high xylene concentrations may cause
<br /> in nausea,vomiting,and abdominal pain,eye,nose,and throat irritation,respiratory tract Irritation leading to pulmonary edema(fluid in
<br /> lung),drowsiness,and unconsciousness Direct eye contact can result in conjunctivitis and corneal bums Ingestion may cause a burning sensation
<br /> in the oropharynx and stomach and transient CNS depression Chronic Effects:Repeated or prolonged skin contact may cause drying and defat-
<br /> ung of the skin leading to dermautis Repeated eye exposure to high vapor concentrations may cause reversible eye damage,peripheral and central
<br /> neuropathy,and liver damage Other symptoms of chronic exposure include headache,fatigue.irritability.chronic bronchitis,and GI disturbances
<br /> such as nausea,loss of appetite,and gas
<br /> FIRST AID Emergency personnel should protect against exposure Eyes Do not allow victim to rub or keep eyes tightly shut.Gently lift eyelids
<br /> and flush immediately and continuously with flooding amounts of water until transported to an emergency medical facility Consult a physician
<br /> immediately Skin Quickly remove contaminated clothing Rinse with flooding amounts of water for at least 15 min Wash exposed area with soap
<br /> and water For reddened or blistered skin,consult a physician Carefully dispose of contanunated clothing as it may pose a fire hazard Inhalation
<br /> Remove exposed person to fresh air and support breathing as needed Monitor exposed person for respiratory distress Ingestion:Never give
<br /> anything by mouth to an unconscious or convulsing person Contact a poison control center and unless otherwise advised,do not induce vomiting,If
<br /> spontaneous vomiting should occur,keep exposed persons head below the hips to prevent aspiration(breathing liquid xylene into the lungs)
<br /> Aspiration of a few millimeters of xylene can cause chemical pneumonitis pulmonary edema,and hemorrhage Note to Physicians. Hippunc acid
<br /> or the ether glucurorude of Ortho-toluic acid may be useful in diagnosis of meta-,para- and ortho-xylene exposure,respectively Consider gastric
<br /> lavage if a large quantity of xylene was ingested Proceed gastric lavage with protection of the airway from aspiration,consider endotracheal
<br /> intubation with inflated cuff
<br /> Section 7. Spill, Leak,and Disposal Procedures
<br /> Spill/Leak Notify safety personnel,evacuate all unnecessary personnel,remove all heat and ignition sources,and ventilate spill area Cleanup
<br /> personnel should protect against vapor inhalation and skin or eye contact.If feasible and without undue risk,stop leak Use appropriate foam to
<br /> blanket release and suppress vapors Water spray may reduce vapor,but does not prevent ignition in closed spaces For small spills,absorb on paper
<br /> and evaporate in appropriate exhaust hood or absorb with sand or some non-combustible absorbent and place in containers for later disposal For
<br /> large spills dike far ahead of liquid to contain Do not allow xylene to enter a confined space such as sewers or drains On land.dike to contain or
<br /> divert to impermeable holding area Apply water spray to control fiarnmable vapor and remove material with pumps or vacuum equipment On
<br /> water,contain material with natural barriers,booms,or weirs,apply universal gentn&agent,and use suction hoses to remove spilled material
<br /> Report any release in excess of 1000 lb Follow applicable OSHA regulations(29 CFR 1910 120) Environmental Transport Little bioconcen
<br /> tration is expected Biological oxygen demand 5(after 5 days at 20'C) 0 64(no stated isomer) Ecotoxicity values:LD50,Goldfish, 13 rng/1.f24 hr,
<br /> conditions of bioassay not specified,no specific isomer Environmental Degradation:In the atmosphere,xylenes degrade by reacting with
<br /> photochemically produced hydroxyl radicals with a half-life ranging from 1-1 7 hr in the summer to 10-18 hr in winter or a typical loss of 67-86%
<br /> per day Xylenes are resistant to hydrolysis Soil Absorption/Mobility:Xylenes have low to moderate adsorption to soil and when spilled on land,
<br /> will volatilize and leach into groundwater Disposal.As a hydrocarbon,xylene is a good candidate for controlled incineration Contact your supplier
<br /> licensed contractor for detailed recommendations Follow applicable Federal,state,and local regulations
<br /> Designations OSHA Designations
<br /> Extremely Hazardous Substance(40 CFR 355) Not listed Listed as an Air Contaminant(29 CFR 1910 1000,Table Z-1-A)
<br /> Listed as a SARA Toxic Chemical(40 CFR 372 65)
<br /> Listed as a RCRA Hazardous Waste(40 CFR 26133) No U239,F003(spent solvent)
<br /> Listed as a CERCLA Hazardous Substance*(40 CFR 302 4) Final Reportable Quantity(RQ).1000 lb(454 kg)[*per Clean Water Act,
<br /> Sec 311(b)(4),per RCRA,Sec 30011
<br /> Section 8. Special Protection Data
<br /> Goggles Wear protective eyeglasses or chemical safety goggles,per OSHA eye-and face-protection regulations(29 CFR 1910 133) Because
<br /> contact lens use in industry is controversial,establish your own policy Respirator:Seek professional advice prior to respirator selection and use
<br /> Follow OSHA respirator regulations(29 CFR 1910 134)and.if necessary,wear a MSHA/NIOSH-approved respirator For concentrations>1000
<br /> ppm,use any chemical cartridge respirator with organic vapor cartridges,any powered,air-purifying respirator with organic vapor cartridges,any
<br /> supplied-air respirator,or any self-contained breathing apparatus For emergency or nonroutine operations(cleaning spills,reactor vessels,or
<br /> storage tanks),wear an SCBA Warningi Air-purifying respirators do not protect workers in oxygen-deficient atmospheres If respirators are used,
<br /> Other Wear chemically protective gloves,boots.aprons,and gauntlets to prevent all skin contact.With breakthrough times>8 hr,consider
<br /> polyvinyl alcohol and fluorocarbon rubber(Viton)as materials for PPE Ventilation Provide general acid local exhaust ventilation systems to
<br /> maintain airborne concentrations below the OSHA PELs(Sec 2) Local exhaust ventilation is preferred because it prevents contaminant dispersion
<br /> into the work area by controlling It at Its source(103)Safely Stations:Make available in the work area emergency eyewash stations,safety/quick-
<br /> drench showers,and washing facilities Contaminated Equipment. Separate contaminated work clothes from street clothes Launder contami-
<br /> nated work clothing before wearing Remove this material from your shoes and clean PPE Comments.Never eat,drink.or smoke in work areas
<br /> Practice good personal hygiene after using this material,especially before eating,drinking,smoking,using the toilet,or applying cosmetics
<br /> Section 9. Special Precautions and Comments
<br /> Storage Requirements Store in clearly labelled,tightly closed,containers in a cool.well-ventilated place,away from strong oxidizing materials
<br /> and heat and ignition sources During transferring operations,electrically ground and bond metal containers Engineering Controls To reduce
<br /> potential health hazards,use sufficient dilution or local exhaust ventilation to control airborne contaminants and to maintain concentrations at the
<br /> lowest practical level Use hermetically sealed equipment,transfer xylene in enclosed systems,avoid processes associated with open evaporating
<br /> surfaces,and provide sources of gas release with enclosures and local exhaust ventilation Use Class L Group D electrical equipment Administra-
<br /> tive Controls Establish air and biological monitoring programs and evaluate reguh[rly Consider preplacement and periodic medical examinations
<br /> including a complete blood count,a routine urinalysis,and liver function tests Consider hematologic studies if there is any significant contamination
<br /> of the solvent with benzene If feasible,consider the replacement of xylene by less toxic solvents such as petrol(motor fuel)or white spirit.Before
<br /> carrying out maintenance and repair work,steam and flush all equipment to remove any xylene residues
<br /> Transportation Data(49 CFR 172 101)
<br /> T Shipping Name Xylenes Packaging Authorizations Quantity Limitations Vessel Stowage Requirements
<br /> Hazard Class 3 a) Exceptions 173 150 a)Passenger.Aircraft,or Railcar 5L a)Vessel Stowage B
<br /> No UN1307 b)Nonbulk Packaging 173 202 b)Cargo Aircraft Only 60L b)Other —
<br /> DOT Packing Group H c)Bulk Packaging 173 242
<br /> DOT Label Flammable Liquid
<br /> Special Provisions(172 102) TI
<br /> MSDS Cotlechon References 26,73,89,lot], 101, 103,124 126.127,132,133,136,139,140,148,149,153, 159,163, 164,167,171,174, 176,180
<br /> Prepared by MJ Wurth,BS,Industrial Hygiene Review PA Roy,MPH,CIH Meilkal Review W Silverman,MD
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