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ARkEMA SAFETY DATA SHEET <br /> CERTINCOATO TC-100 Coating Material <br /> Repeated inhalation administration to rat/ affected organ(s): lung / signs: respiratory irritation, <br /> inflammation, lung edema, changes in blood cell counts / Local irritation of the respiratory system <br /> (extent of injury depends on severity of exposure) <br /> Genotoxicity <br /> Assessment in Vitro: <br /> Both positive and negative responses for genetic changes were observed in laboratory tests using: <br /> bacteria, animal cells <br /> Genotoxicity <br /> Assessment in Vivo: <br /> No genetic changes were observed in laboratory tests using: mice <br /> Developmental toxicity <br /> Exposure during pregnancy. oral (rat) / No birth defects were observed. <br /> Reproductive effects <br /> Exposure prior to mating. dietary (rat) / No toxicity to reproduction <br /> Data for Stannane, dibutyldichloro- (683-18-1) <br /> Acute toxicity <br /> Oral: <br /> Toxic if swallowed. (rat) LD50 = 219 mg/kg. <br /> Dermal: <br /> Harmful in contact with skin. (estimate based on composition) <br /> Inhalation: <br /> Fatal if inhaled. (rat) 4 h LC50 = 0.06 mg/I. (dust/mist) <br /> Fatal if inhaled. (rat) 1 h LC50 = 0.1 mg/I. (dust/mist) <br /> Specific target organ toxicity - single exposure: <br /> Causes damage to organs. (thymus) <br /> Skin Irritation: <br /> Causes severe skin burns. (rabbit) (5 min) <br /> Eye Irritation: <br /> Causes serious eye damage. (rabbit) <br /> Skin Sensitization: <br /> May cause allergic skin reaction. Buehler method. (guinea pig) Skin allergy was observed. <br /> Repeated dose toxicity <br /> Repeated dietary administration to rat / affected organ(s): thymus / signs: changes in organ structure or <br /> function <br /> Specific target organ toxicity - repeated exposure: <br /> Product code: 13I1300 Version 3.2 Issued on: 07/18/2018 Page: 10 / 15 <br /> Page 10/16 <br /> Quick-FDS [19050-00814-08435-011984]-2020-02-26-00:13:35 <br />