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Test Type: Mutagenicity (mammal cell test): chromosome aberration. <br /> Test system: Chinese hamster ovary cells <br /> Metabolic activation: with and without metabolic activation <br /> Method: OECD Test Guideline 473 <br /> Result: positive <br /> Test Type: Ames test <br /> Test system: Salmonella typhimurium <br /> Metabolic activation: with and without metabolic activation <br /> Method: OECD Test Guideline 471 <br /> Result: positive <br /> Test Type: In vivo micronucleus test <br /> Species: Mouse <br /> Cell type: Bone marrow <br /> Application Route: Oral <br /> Method: OECD Test Guideline 474 <br /> Result: negative <br /> Carcinogenicity <br /> Limited evidence of carcinogenicity in animal studies <br /> Suspected human carcinogens <br /> IARC: 2A - Group 2A: Probably carcinogenic to humans (Dichloromethane) <br /> NTP: No ingredient of this product present at levels greater than or equal to 0.1% is <br /> identified as a known or anticipated carcinogen by NTP. <br /> OSHA: No component of this product present at levels greater than or equal to 0.1% is <br /> on OSHA's list of regulated carcinogens. <br /> Reproductive toxicity <br /> No data available <br /> Specific target organ toxicity - single exposure <br /> Inhalation - May cause drowsiness or dizziness. - Central nervous system <br /> Specific target organ toxicity - repeated exposure <br /> No data available <br /> Aspiration hazard <br /> No data available <br /> 11.2 Additional Information <br /> Repeated dose toxicity - Rat - male and female - Oral - 104 Weeks - NOAEL (No observed <br /> adverse effect level) - 6 mg/kg <br /> Repeated dose toxicity - Rat - male and female - Inhalation - 104 Weeks <br /> RTECS: PA8050000 <br /> Dizziness, Nausea, Vomiting, narcosis, Cough, irritant effects, Unconsciousness, Shortness <br /> of breath, respiratory paralysis, somnolence, depressed respiration, CNS disorders, <br /> inebriation <br /> Risk of corneal clouding. <br /> The following applies to aliphatic halogenated hydrocarbons in general: systemic effect: <br /> narcosis, cardiovascular disorders. Toxic effect on liver, kidneys. <br /> Dichloromethane is metabolized in the body producing carbon monoxide which increases <br /> and sustains carboxyhemoglobin levels in the blood, reducing the oxygen-carrying capacity <br /> of the blood. <br /> Sigma-Aldrich - 270997 <br /> Page 9 of 12 <br /> The life science business of Merck KGaA, Darmstadt, Germany hAIllipORle <br /> operates as MilliporeSigma in the US and Canada sirmMa <br />