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EXTOXNETP111-MANEB <br /> http://acc.orst.edu/cgi-bin/mfs/01/pips/maneb.htm <br /> EXTOXNET <br /> Extension Toxicology Network <br /> Pesticide Information Profiles <br /> A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State <br /> University, the University of Idaho, and the University of California at Davis and the Institute for <br /> Environmental Toxicology, Michigan State University. Major support and funding was provided by the <br /> USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. <br /> EXTOXNET primary files maintained and archived at Oregon State University <br /> Revised June 1996 <br /> Maneb <br /> Trade and Other Names: Trade names include Farmaneb, Manesan, Manex, Manzate, Nereb, <br /> and Newspor. <br /> Regulatory Status: Maneb is a practically nontoxic ethylene(bis)dithiocarbamate in EPA toxicity <br /> class IV. It is registered as a General Use Pesticide (GUP). Labels for products containing mancozeb <br /> must bear the Signal Word CAUTION. <br /> Chemical Class: ethylene(bis)dithicarbamate <br /> Introduction: Maneb is an ethylene(bis)dithiocarbamate fungicide used in the control of early and <br /> late blights on potatoes and tomatoes and many other diseases of fruits, vegetables, field crops, and <br /> ornamentals. Maneb controls a wider range of diseases than other fungicides. It is available as granular, <br /> wettable powder, flowable concentrate, and ready-to-use formulations. <br /> Formulation: It is available as granular, wettable powder, flowable concentrate, and ready-to-use <br /> formulations. <br /> Toxicological Effects: <br /> • Acute toxicity: Maneb is practically nontoxic by ingestion, with oral LD50 values of greater than <br /> 5000 mg/kg to 8000 in rats, and 8000 mg/kg in mice [1,3]. Via the dermal route, it is slightly toxic, <br /> with a dermal LD50 in rats of greater than 5000 mg/kg [3]. Inflammation or irritation of the skin, <br /> eyes, and respiratory tract have resulted from contact with maneb [1,8]. The 4-hour inhalation LC50 <br /> is greater than 3.8 mg/L, indicating slight toxicity. Acute exposure to maneb may result in effects <br /> such as hyperactivity and incoordination, loss of muscular tone, nausea, vomiting, diarrhea, loss of <br /> appetite, weight loss, headache, confusion, drowsiness, coma, slowed reflexes, respiratory paralysis, <br /> of'4 <br /> 5/15/00 11:09 AM <br />