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ATOXNET PIP-DIURON ',"p:Hace.orst.edu/cgi-bin/mfs/01/pips/diuron.htm <br /> EXTOXNET <br /> Extension Toxicology Network <br /> Pesticide Information Profiles <br /> A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State <br /> University, the University of Idaho, and the University of California at Davis and the Institute for <br /> Environmental Toxicology, Michigan State University. Major support and funding was provided by the <br /> USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. <br /> EXTOXNET primary files maintained and archived at Oregon State University <br /> Revised June 1996 <br /> Diuron <br /> Trade and Other Names: Trade names for products containing diuron include Crisuron, Diater, <br /> Di-on, Direx, Karmex, and Unidron. It is often used in combination with other pesticides such as <br /> bromacil and hexazinone. <br /> Regulatory Status: Diuron is a General Use Pesticide (GUP). The U.S. EPA classifies it as <br /> toxicity class III - slightly toxic. However, products containing diuron bear the Signal Word WARNING <br /> because it can irritate the eyes and throat. <br /> Chemical Class: substituted urea <br /> Introduction: Diuron is a substituted urea herbicide used to control a wide variety of annual and <br /> perennial broadleaf and grassy weeds, as well as mosses. It is used on non-crop areas and many <br /> agricultural crops such as fruit, cotton, sugar cane, alfalfa, and wheat. Diuron works by inhibiting <br /> photosynthesis. It may be found in formulations as wettable powders and suspension concentrates. <br /> Formulation: It may be found in formulations as wettable powders and suspension concentrates. <br /> Toxicological Effects: <br /> • Acute toxicity: Diuron is slightly toxic to mammals. The oral LD50 in rats is 3400 mg/kg. The <br /> dermal LD50 is greater than 2000 mg/kg [4,8]. Some signs of central nervous system depression <br /> have been noted at high levels of diuron exposure. For humans, the only reported case of acute, oral <br /> exposure to the herbicide produced no significant symptoms or toxicity [4,8,10]. <br /> • Chronic toxicity: Male rats given extremely high doses of diuron over a 2-week period showed <br /> changes in their spleen and bone marrow. Other chronic effects attributed to moderate to high doses <br /> I of 3 5/12/00 2:22 PM <br />