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04/02/2001 Dt1 Pont Page 7 of 12 <br /> Material Safety Data Sheet - 12395S - CHROMAPREMIER <br /> High doses in laboratory animals have shown non specific effects such as <br /> irritation, weight loss, moderate blood changes. <br /> MEDIUM MINERAL SPIRITS <br /> Laboratory studies with rats have shown that petroleum distillates can cause <br /> kidney damage and kidney or liver tumors. These effects were not seen in <br /> similar studies with guinea pigs, dogs, or monkeys. <br /> Several studies evaluating petroleum workers have not shown a significant <br /> increase of kidney damage or an increase in kidney or liver tumors. <br /> MELAMINE RESIN <br /> This chemical is a formaldehyde donor. Formaldehyde is an IARC, NTP or OSHA <br /> carcinogen and has shown mutagenic activity in laboratory cell culture tests. <br /> Formaldehyde has produced tumors in the nasal passages of laboratory animals <br /> when exposed to high concentrations for a two year period. Epidemiology <br /> studies conducted to date have not found evidence of formaldehyde related <br /> tumor induction in humans. <br /> WARNING: This chemical is known to the State of California to cause cancer. <br /> METHYL AMYL KETONE <br /> Ingestion studies on laboratory animals showed that very high oral doses <br /> caused increased liver and kidney weights. <br /> METHYL ETHYL KETONE <br /> High concentrations have caused embryotoxic effects in laboratory animals. <br /> Liquid splashes in the eye may result in chemical burns. <br /> Methyl ethyl ketone has been demonstrated to potentiate (i .e. , shorten the <br /> time of onset) the peripheral neuropathy caused by either n-hexane or methyl <br /> n-butyl ketone. MEK by itself has not been demonstrated to cause peripheral <br /> neuropathy. <br /> METHYL ISOAMYL KETONE <br /> Extremely high oral doses in laboratory animals have shown weight changes in <br /> various organs such as the liver, kidney and adrenal gland. <br /> In addition liver injury was observed. <br /> METHYL ISOBUTYL CARBINOL <br /> Extremely high concentrations have caused blood changes and weakness in <br /> laboratory animals. <br /> Liquid splashes in the eye may result in chemical burns. <br /> Male rats exposed to very high airborne levels showed an increase in kidney <br /> weights. These effects were not seen in male rats exposed to lower <br /> concentrations, or in female rats at the same level . <br /> METHYL ISOBUTYL KETONE <br /> Individuals with preexisting diseases of the central nervous system or lungs <br /> may have increased susceptibility to the toxicity of excessive exposures. <br /> Recurrent overexposure may result in liver and kidney injury. <br /> N-BUTYL ALCOHOL <br /> May cause abnormal blood forming function with anemia. <br /> Liquid splashes in the eye may result in chemical burns. <br /> PETROLEUM NAPHTHA <br /> Laboratory studies with rats have shown that petroleum distillates can cause <br />