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04/02/2001 I3-Lx Pont Page 8 of 12 <br /> Material Safety Data Sheet - 12395S - CHROMAPREMIER <br /> Several studies evaluating petroleum workers have not shown a significant <br /> increase of kidney damage or an increase in kidney or liver tumors. <br /> PRIMARY AMYL ACETATE <br /> Recurrent overexposure may result in liver and kidney injury. <br /> PROPYLENE GLYCOL MONOMETHYL ETHER ACETATE <br /> May cause moderate eye burning. <br /> Recurrent overexposure may result in liver and kidney injury. <br /> TITANIUM DIOXIDE <br /> In a lifetime inhalation test, lung cancers were found in some rats exposed to <br /> 250 mg/m3 respirable titanium dust. Analysis of the titanium dioxide <br /> concentrations in the rat's lungs showed that the lung clearance mechanism was <br /> overwhelmed and that the results at the massive 250 mg/m3 level are not <br /> relevant to the workplace. <br /> TOLUENE <br /> Chromosomal changes in the circulating blood of exposed workers have been <br /> reported. The significance of these reports is unclear because of exposure to <br /> other substances. <br /> Individuals with preexisting diseases of the central nervous system may have <br /> increased susceptibility to the toxicity of excessive exposures. <br /> Recurrent overexposure may result in liver and kidney injury. <br /> High airborne levels have produced irregular heart beats in animals and <br /> occasional palpitations in humans. Rats exposed to very high airborne levels <br /> have exhibited high frequency hearing deficits. The significance of this to <br /> man is unknown. <br /> WARNING: This chemical is known to the State of California to cause birth <br /> defects or other reproductive harm. <br /> VM&P NAPHTHA <br /> Laboratory studies with rats have shown that petroleum distillates can cause <br /> kidney damage and kidney or liver tumors. These effects were not seen in <br /> similar studies with guinea pigs, dogs, or monkeys. <br /> Several studies evaluating petroleum workers have not shown a significant <br /> increase of kidney damage or an increase in kidney or liver tumors. <br /> XYLENE <br /> Individuals with preexisting disease of the central nervous system, kidneys, <br /> liver, cardiovascular system, lungs, or bone marrow may have increased <br /> susceptibility to the toxicity of excessive exposures. <br /> Can be absorbed through the skin in harmful amounts. <br /> Recurrent overexposure may result in liver and kidney injury. <br /> Canada classifies Xylene as a developmental toxin as high exposures to xylenes <br /> in some animal studies have been reported to cause health effects on the <br /> developing fetus/embryo. These effects were often at levels toxic to the adult <br /> animal . The significance of these effects to humans is not known. <br /> 1, 6 HEXAMETHYLENE DIISOCYANATE <br /> May cause temporary upper respiratory and/or lung irritation with cough, <br /> difficult breathing, or shortness of breath. <br /> ****** SECTION 4 - First Aid Measures ****** <br />