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�I
<br /> J
<br /> @rt�Lp',i1 I _ may.
<br /> pf 7205 Phenoctide 'xax fi
<br /> E z
<br /> THERAP CAT: Anti I# l
<br /> { tl� pyretic, analgesic, paralysis, convulsions, coma, greenish Or'smoky-colorer -. eilhl}eliihalein as an
<br /> 7205. Phenoctide: NN-Diethy.I-N°(2=(4-(1,1;3,3-tetra- aline,necrosis oflmauth and G.I. tract;icterus, death drool„� j?.-Use the color
<br /> tl ° methylbutyl)phenaxyJethyl]beruereemethunaminium chloride; respiratory failure,sometimes from cardiac arrest. gge1ol%' �et.c`,Usable with a
<br /> f � belt=ylditihyl-2-((p.I,1,3,3-tetrarnethylbatyl)phenoxy)cthyl- Ental d°se is 15 g but death from as little as one grA,n A g t� tt6 deep red,abo%
<br /> been reported. Fatal
<br /> ammonium chloride;.d-p-tert-octylphenoxyethyldiethylben- P poisoning root' also occur by s`Jeta ' ER”.CAT: Cathar
<br /> Ili zylammanium chloride; Octaphert. C27H47C1N0; mo] wt
<br /> absorption FoElow%ing application to large areas. Ch-,P.
<br /> CAT(vET): H
<br /> 5 d? a 432.11. C 75.05%, H 9.80%, Cl 8.21%, N 3.24%, O 3.70%. poisoning with renal and'hepatic damage may occur
<br /> d I Prepn: Goldberg, Besly,Brit. pat. 703,477 (1954 to-Word industrial contact, See C.J.Polson, R. N. Tattersall,Clrn X09 PitenolphtEtaL
<br /> f 1 i' 311)-isobenzo urs
<br /> Blenkinsop);Erekaev, GA. 54, 12483i (1960). col Toxicology (Lippincott, Philadelphia, 1969) pp 51 ' i' �� f
<br /> Ea� p�4t 362.29. C 66.3
<br /> I,+ ]aeicfimann, Keplinger in Patty's Industrial 7Yygierte nR e HUrom an alcohol
<br /> I Tnxteology Vol 2A,G, D. Clayton,F.E.Clayton,Eds (ill16",,t F kdditinn of 2 inols
<br /> I r t cH CH C H Iey-Interscience, New York, 3rd ed., 1981') pp 2567 2584 e�r
<br /> s e olio [5] 8, 165
<br /> '� �` 13 13 I z s USE: Asa general disinfectant,either in solo or mixed with:
<br /> + Ct' slaked lime,etc.,for toilets,stables,cesspools,floors,dram
<br /> CH3CCH2C — nCRZCt42n-.CH ZC6H5
<br /> r I I I I etc.; for the manuf of colorless or light-colored artafidal _ Nap
<br /> .r CHa CH3 Czl[5 resins, many medical-and industrial organic cumpds
<br /> and04 i
<br /> it dyes; as a reagent in chemical analysis. Pharmaceutic e+ }t �
<br /> : 3 -
<br /> i; (Preservative). i
<br /> Crystals from ethyl acetate. 'mp 112-114' (Goldberg, THERAP CAT: Aqueous soln as topical ani=sthetic; tgplcal�'..
<br /> y
<br /> antlsepfic;'topical3ant,pruritic. I
<br /> l` Besl );mp'95'(Erekaev). yz
<br /> gI yJ IIS h rill RAP CAT(VET): Antiseptic caustic. Topical anesthetic,
<br /> USE: Orthophosphate as lubricant: Semmens, Summers. pruritic skin conditions. Has been used internally ah , i,`� .
<br /> Ill Smith, Brit.pat. 790,056 (1958 to I.C.I.). Wl
<br /> ternally as an antiseptic.
<br /> i lI THERAP CAT: Topical anti-infective. r
<br /> 7207. Phenoldsulfonic:Acfd. 4-H {rt widish-brown ran-
<br /> ('I I 7.206. Phenol. Carbolic acid; henic acid; hen lic acid; f y y ydroxy-l,3-benzehtdl,—_ der, Dec in air
<br /> phenyl hydroxide; hydroxybenz ne; oxybenzone. yC H O; su1.unic acid; 4-h drox -m-benzerted[sulfanic acid;f l pbe
<br /> i} 6 6 nol-2,Q-disulfonic acid. C6H60[S2; mol wt 254;23 tri > , bsorption max
<br /> loaf wt 94.11. C 76.577., H 6.43%, O 17.00%x. Obtained 28,34%,H 2,38%,'10 44.05%, S 25.22%, Conveniently ts'oolorless,as is
<br /> f j from coal tar; or made by fusing sodium be
<br /> nzenesulfonate Y prepd vz, .
<br /> l I i,i with NaOH, or by heating monochlorobenzeno with a by hydrolysis of the dichloride which is obtained by thc.ag , 110.i Phenol hthali
<br /> q et aL,f chlorosulfo'nic acid on phenol at room temp; Pollak r�otc acid;-decaloriz
<br /> t NaOH under high pressures The crystalline article of et aL,Monatslu 46,395(1925). Monograph: E. E.Gilbert+ droigtriphenylmet
<br /> commerce contains at least 98% phenol. Review of mf > '
<br /> l P g Sulfonation and Related;Reactions(Interscience,New Ya& o 1
<br /> x 1 processes: A. Dierichs. R. 'Kubicka, Phenole anPP;d Basen, 1965) 529 l n 'ttvr 20.33. C 74.1
<br /> d Vorkommen and Gewinnung (Akademie-Verlag, Berlin, } t t i.'Phenolphthalei
<br /> i 1958)472 ld',`Kastle-M er re
<br /> pp;Faith, Keyes &Clark's Industrial Chemicals, { a ty
<br /> w, R A. Lowenbeim, M. K. Moran, Eds. (Wiley-Interscience, II pH x 'aV p�?g g phenolphth[
<br /> New York, 4th ed., 1975)pp 612-623. Use in treatment of $pall '` t " aoIX.h'iistd H2O and
<br /> rAi �>fanoV
<br /> spasticity: D. E. Garland e[ al., Olin Orrhop. 165, 217 •,Detailed dire+
<br /> iI ill ai
<br /> I (1992.); eidem, Arch. Phys ]fled. Rehab. 65, 243 (1984). ; � l,)kE �kec69,Bull.Sac. r
<br /> Review of use in pain relief: K: r`�
<br /> M. Woad,Pain 5,205-229 �{ , t}k+` ` {1947}.
<br /> (1978). Review of toxicology: H. Babich, D. L. Davis,
<br /> I Regul. Toxico4 Pharmacol. 1, 90-109 (1981). Toxicity: W. S BQaH �c'r r Kt's-i' Ho
<br /> . Il`
<br /> B. D6chmann, S. Wither-up, J. Pharmacol. Exp. Ther. 80, t 01
<br /> 233(1944). Review. C.Thurman in Kirk-Othmer EncycIo- Deliquescent needles, vague melting range from,a'
<br /> peIntersclalti°.
<br /> dis of Chemical Technology Vol. 17 (Wile
<br /> I trA Y- ience, lOD°. becomp nbave 100°: Freely soI`in water, metlitinbir:�
<br /> ;
<br /> New York, 3rd ed., 1982)pp 373-384. Practical/ #y insol in ether. pair ether.
<br /> Usr: In the manuf.of aminophenoldisuffontc acids,i4h.idil i
<br /> fI 1 off are intermediates in the dye industry. `3 j ,r i
<br /> tJ�l i 7208. Phenolphthalein" 3,3-Bis(4-hydroxyplten�l)t1 F 7 t'
<br /> (31f)-isobenzofuranone, 3,3-bis(p-hydroxyphcnyl)phih41idb odorless crystals,mF
<br /> t a-(p-hydroayph,"y1)-a'-(4-Oxo-2.5-cyclohexadt en Lyltde oaf;
<br /> ene)-o-toluic acid;' Chocolax; Darmol; Laxtn C2 R11-1412, 4:fir• The a
<br /> n °sure to air or of
<br /> ll� mol wL 318.31. C.75.467., H4.43%, O 20.107Pre0dzby;°', trgg� a reagent fc
<br /> !; Colorless, acicular crystals or white, crystalline_ mass; condensing phenol with phthalic anhydride: Baeybrt alt; a
<br /> characteristic odor. Poisonous and caustirl Prone to redden 202,69(1880);Herzog, Chem.Zig, 51,134(1927) 1u69cherj � p
<br /> ri on exposure to air and light, hastened by presence of alka- U.S. pat. 2,192,485 (1940 to Ex Lax); Gamrath IJ.S,P�rAs 211 '; heaolphthalo
<br /> r E y linity. d 1.071, When.free from water and cresols it con-
<br /> 2,522,939(1950 to Monsanto). n• art erteiieihanol; o-(bu
<br /> geals at 4.1"and melts at 43'. .Ultrapure material mp 40.85'. alstlihydtoxyphenyl
<br /> I �l of The commercial product contains an impurity which raises p ; noxybenzhydryl)ben
<br /> 1 4'' the mp. by 182'. Flash pt° closed cup: 175°F(79°C). n8 iZ l +f dro.xymethylphea}
<br /> 1.5425. pKa at 25' = 10.0. pH of aq solos about 6.0. It is a?i" y mol wt 306,34.
<br />{ n liquefied by mixing with about 817. water. One gram dis- '•Iiubacher, T.
<br /> E l�
<br /> �h solves in about 15 ml water, 12 ml benzene•,very sol in alco- / off i tz 'Geller,Arch P
<br /> ii bol, chloroform, ether, glycerol, carbon disulfide, petrola- 81141243 (1962 to
<br /> tum, volatile and fixed ails,'aq alkali hydroxides. Almost
<br /> insol in petr ether. LD50 orally in rats: 530 mg/kg(Deich- F ){
<br /> f r �' I mann,Witherup). Keep well closed and protected from light. No
<br /> ill`I�yl Do riot handle with bare hands �#
<br /> Incompat. Phenol coagulates collodion; liquefies or be-
<br /> lob i�Ci'I comes semiliquid when triturated with acetanilids butyl- ON
<br /> fl fI
<br /> chloral hydrate, camphor, monobromated camphor, chloral I
<br /> I I }I�.J, hydrate,diuretin,lead acetate,menthol,-naphthalene, naph- Minute, triclinicicrystais, often twinned. mp 258 2G aab as
<br /> d I0 thol, acetophenetidin, pyrogailot, resorwA°l, salol, sodium1.299: Color; White or yellowish-white, see also "!,Ad �l y
<br /> phosphate, thymol, urethane, chloralamide, terpin hydrate. Phenolphthalein. Almost insoluble in water. On-gram ts �I
<br /> Ik�j i Ammonium salt, C6H9N0, arnmanium.phenate, ammonf- solves in 12 ml alcohol,in:About 100 ml ether Verysl�gh
<br /> am carbolate. White to pink cryst masses. Sol in water. sol�J in-chloroform.;]. ystais from dil aico Sodium salt, C6HENaO,phenolate sodium., usE: A 1% alcoholic soln as an indicator to titrat)ons biti neacetate Cz3H2QC
<br /> Aqueous solutionwith.phenolate sodium, Chloraseptic. mineral and organic acids and most alkalies. Not spltau AM-P'.171-174°7 Sol
<br /> human Toxicity; Ingestion of even small amounts may for ammonia.. Vent'sensitive to CO.,and in esttmatin&cafi" acetate, C H O,
<br /> cause nausea, vomiting, circulatory collapse, tachypnea, bonates the liq must be boiled. Borax can be titrated3M ,, 04::106'.. Practical]
<br /> Page 1150 Consult the cross index before using this section. s.'41P ,
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