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SECTIONTHREE Technical Approach <br /> PM(x) = Reference Dose, a cheaucal-specific dose value based on a no- <br /> observed adverse effect level(i e,threshold level) <br /> Hazard quotients may be summed for all compounds of concern and pathways to yield an overall <br /> hazard index However, this approach is conservative because the nature of non-carcmogemc effects <br /> (n e, organ injury) does not always support a basis for additivity In reality, non-carcinogenic effects <br /> may or may not be additive Hazard indexes will be calculated for each exposure pathway and <br /> population, under average and RM E assumptions When is hazard quotient is greater than 1, it will be <br /> recalculated by only summing exposures for chemicals which have the same toxic manifestation of <br /> effect the same target organ, as specified by agency guidance <br /> The product of the human health screening evaluation is thus a compilation of carcinogenic risks and <br /> non-carcinogenic hazards, for each area of concern at the site, for each pathway, and each receptor <br /> population Non-carcinogenic hazards are considered acceptable of hazard indexes are below 10 <br /> 1 0 <br /> T1199rano09NAL4ToommRE?ow mm7-AL*4m973wmA%sNA 3-9 <br />