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kUT0M0TIVE�CA,,OLI.NIE 65-32
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<br /> N,s
<br /> snoncaneous motor activity ane :educed performance connectee with
<br /> disturbances of the motor coorainat:,on system: howevertheseverity of
<br /> these effects does not indicate serious toxic damage to the CNS'. The
<br /> study concluded that MTBE "does not even mirumally increase the
<br /> neurologic effects with resaect to gasoline itself.* The level of
<br /> exposure or the species which were tested were nor- reported (2293)
<br /> t:-Bualcohol
<br /> At,high concentrations; c-butyl alcohbl causes narcosis in animals_
<br /> and- it—is—expectedto°{cause;4 she same effect in h«*n*+s. rOtherr, than
<br /> slight skin ;Irritation.,��no `effects have "'been reported L from industrial
<br /> exposure. The oral LDso is the rat is 3500 mg/kg (46) . x r
<br /> ,r
<br /> Ethanol.
<br /> ir
<br /> ELhantol J is 'irr`stating; co 'the eyes,„arid' mucous'membranes. It is
<br /> also °a CNS depressanc.-, ,TheA`,acute).,taxxcity ,of,4ethanol is low for both
<br /> animals ``"arid" man. a Overexposure causes,, ataxia;, incoordination and
<br /> drowsiness (2,46) An
<br /> 14'Loral LD s o of ,14 g/kg 'was reported for the rat
<br /> (47)
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<br /> Methanol N
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<br /> •1 _
<br /> Methanol r causes' Joptic , neuropathy, , and- ,rmetabolic acidosis.
<br /> Poisonik l , has occurred r{ primarily from `ingestion "� of adulterated
<br /> alcoholic ,beverages After °ingestion there%urs` A, latency period , of 18
<br /> to 48 hours after which exposed individuals develop,-1symptoms of nausa&,
<br /> tabdomiiaal- pain, headache and shortness off breath., '';,Visual symptoms
<br /> range frog .blurred .,ot. doukila vision, to �changesta�%its 'color 'perception,
<br /> coasat3cted; visual "fields
<br /> and completek,bliadaess: 40ther symptoms of
<br /> Antoxication include°,dimziness, behaviorah ^distn"a'nces'; neuritis and
<br /> ti acidosis:
<br /> The. degree "of .acidosis,'Mies' ,been found `oto parallel the
<br /> r saveritp`,of the, poisoning.,. Evidencevl'suggests that exposure to 'vapor
<br /> concentrations of 200-375 ppm causes recurrent' headaches and visual
<br /> disturbances are seen at vapor levels of 1200-8300'ppm (2,46) An oral
<br /> Us. of 13 g/kg was reported in the rat (47)
<br /> Tri -ortho-cresol nhos2hate (TOCP)
<br /> TOCP k affects the',,-spinal cord and peripheral nervous system-
<br /> Sympcoms of acute exposure, including nausea, vomiting, diarrhea and
<br /> abdominal 'pain. are followed by a latent period of 3 to 30 days. At
<br /> this time, there is muscle soreness, numbness of fingers. calf muscles
<br /> 'and toes which progresses to foot and wrist drop. These effects are
<br /> manifested after ingestion. inhalation or dermal absorption (54) An
<br /> oral LDso of 1160 mg/kg has been reported in the rat (47) Hore
<br /> information on TOCP can be found in Chapter 49 of the Installation
<br /> Restoration Program Toxicology Guide, Volume 2.
<br /> 6/87
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