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- __ __,-- TCM0TI4E-CASOLI:tiTE <br />{ <br /> Tetramethyl lead affects the nervous system in and =_- and causes <br /> signs of increased irritability. Althougn not d.ocst=anred, it Ls <br /> e=ecced to produca psychoses, mamma, and convulsions I:. _mans (46) <br /> :a the rat, an oral IBea of 109 mg/kg was reporred (47) . <br /> r�! It is likely that intoxication by tatramethyl lead will be similar <br /> co chat caused by tecraethvl lead (46) Information on tetraethyl lead <br /> can be found in Chapter 54 of the Installacton Restoration Program - <br /> Toxteology Guide, Volume 2. <br /> ti <br /> (MMT) <br />` In its concencratad form. MMT is highly toxic by all routas of <br /> exposure. The primary site of action in animals is the GHS. where the <br /> effects of MEM are siMilar to these caused by tatraarhyl lead. The <br /> r oral LD., is the rat is 50 mg/kg. Human exposure data are limited. It <br /> fs expeecad that when MHr is blended with fuels, it has a low order of <br /> .ox3.Q2.Cy <br /> Coneencratad KHT penetrates the skin readily When 5-15 mL was <br /> spilled on a worker's ski=t, nausea. headache and giddiness resultad in <br /> a 2-5 minuta period; however, gasoline solutions are not as readily <br /> absorbed as tha pure material (2,1937,1409) . <br /> 4Myleng dibramidn' <br /> /MB) i <br /> ` IDB is irritat1=g to the 0,700 and M=aun mombranon. Yz aLso <br /> cuusea symptoms of C83S dopresnion. Acuc a enpomwan have ramilCcA in <br /> I=S, livor and kidney damago (1745,1739,38.54). EDU im creitogonie <br /> In rodanrs by oral, inhMI-Cron and dormal rou=a (142.1606.1743,1740. <br /> ALCM ham classified EDS as a suspected human carcinogen with a <br /> reco=Gndaeion that a=poaura bo avoided (3) . The oral Lag. in Cho rat <br /> is 146 mg/kg (1739) . More information on EDB can be found in Chapcar <br /> 1 - 45 of the Installation Restoration Program Toxicology Guide. Volume 2. <br /> 1?-Dichlcr2gShane <br /> Acuta ingestion or inhalation of 1.2-aichloroerhane results in <br /> symptoms of CNS depression, gastrointestinal upset and systemic injury <br /> to the Liver. kidneys and lungs (12) . The oral I.D3o in the rat is 670 <br /> mg/kg (47) . bore information on l.2-dichloroethana can be found in <br /> Chapter 9 of the Installation Restoration Program Toxicology Guide, <br /> -- Volume L. <br /> s <br /> Methpl-c-burrl athar- (MTBE) <br /> In rats. an oral LDsu of 4 mL/kg was reported (1937) . In <br /> recently conducted acute and subchronic tasty, it was reported that <br /> ' I IME caused a deepening of barbiturate sleep, a reduction of <br /> 6/87 <br />