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66-21
<br /> duration or exposure.
<br /> Jana related -.e=facts Ln
<br /> Lisdcace chat thenauzalaglcal cesting
<br /> uncacaausced ' diesel repots
<br /> -euradauressant ( 2334) may also act as a
<br /> In acute dermal studles condu,Cced L:1 ^rabbets.
<br /> all (API ,gray:GY 5 .2/1.29 sulfur i • UMb'er 6 heavy fuel
<br /> at 5 x=ciuceo 'sigzLifican= sigma at toxicity
<br /> S✓kg-' Ih caused severe dermal ' ' '
<br /> atAtia assd ' ,lethar irxi=a=Ion. weight loss xi;
<br /> 8Y• :lettere ti, __ ,�_ anore
<br /> CaXIc he atit.s tY as 37.St_ Necropsy revealed
<br /> P H, gastrointescinal°' Lrri=a=:eon and con , aettce
<br /> Other , grades o r number ,6 wand n 5elr, r,�' 4 ^ + Bested lungs.
<br /> Proeuced',rmLld n to moderate' 2 oils , as ve11 as, diesel oil
<br /> w
<br /> C°X1Gif T+11"' , dermal Lz�iritian 'but' no sysremt'c s pp�rry��
<br /> N,' u�3Cilta rr inti 11 t ,i kC�d«,� t t. th�l ,a�H la�'9S r, r i'a,'
<br /> nde al}M1 S=ud a � S 1 n, 54,'d 4e r, 3 n 3f fie, i
<br /> y' doses4� ran itt 4froan, �,LO`'
<br /> ++ererrM�aPPI�i'td° cn° , rabbitsY$4 ,, , }; ,rr&, *8 1 co 4
<br /> Oban acv¢ Y,,� , ,,r � �,� ,clipped f,,,,frte a fi a a� y� v,�miL/kg
<br /> g 2 tthours qac��, ,' r"� f=,y h r -: The�!'area, a remained
<br /> da ed far G �, M1
<br /> dose r pp ` k Y' This '� h�eh� C , rches ^vete rremnvre4",,)aad
<br /> talr *iied. ti 3.me gthe` Pa
<br /> contlnuee, far,, 5 consecutive _a new
<br /> day ,rest, period i and a r,xf^ r �, r i a days fol loved by a 2
<br /> chlls tesc�,a' r �retaeacM,appiicacicn �£ar��"5 ' consecu='i•Je a"�ays In
<br /> the number 6 h£tial oil+;tAPI o
<br /> degree t'axiczty aravzty� 31.1/I:Z�i sulf�.r� produced
<br /> 2.5 'mf,yk " zaC' »the Lovest,�dase (7,51,' mortalixy at
<br /> sL g)r deal ica'1'^ sighs 'included severe` �etghr. Lass anore�cia and
<br /> g; 8entezZtis,'mss"; :, Lrri'tarti0`ni CCGSS RQCrO�tSyj��reVeal�d6
<br /> G z Yre s ZldTld con~ esCed�k Sw +�w!' henl°rrttaglC
<br /> and ce zrF 3 mottled liv, ,I , ..rtch��sultlfocai necrosis
<br /> ntrilobul'ar , acual�r` 'degeneration_ • °' F
<br /> + ,x p
<br /> oils csusedik�t°nflaiainaclon,', ��'' ")„ , z �,;P,�,In,�'all^ cases. the ;nusabar 6
<br /> ,,de
<br /> acancttasis 'ane parakeratosLlY'cr��geseioti dad"'edema, 'deal necrosis.
<br /> " +" ,r n +r W'L.iYE r' �
<br /> also seen!„ w ' , necresi°s arida de
<br /> buc the severe r, ri N, r�„ generation vete
<br />' sul'fur' ' �r u'� �,,$r,,r ; , tY1r� ash nOc ZS d+` reACt'Y1aS+
<br /> X11'' 3, ,,number-2 oils"'` � " ']' '° �� ,g ,�� chat utth,.115r L/L^.2t
<br /> dei"de ;dersnil� xz 111,1- f7„ �� ;�1Sed�r4fllg}lL��LOSsf� ancrexiaL dnd v
<br /> of"
<br /> , irricatia k various
<br /> j 5 1F 5�1 j i 7 lxf !d,yL n• ! A C i
<br /> from, 5 t4wy�100 :VO Y z r„Swa dS a +5 ,p, a dose roE '.�� 'm �mOrt l,'
<br />' �. N+ r m VO`Grosz; b M r ,��t al Cy ranged,
<br /> -'. renal ;sand" ttep='iCi°Cq� "CA SA' izad'"� sy ns �=,y all,'dOSage,,, live�xs `Lncluded`�"
<br /> ' IPA, �" • + '" , ., gI ,=1Dn-w At Che r LrOlj'+fnL/jc'g Level mulclfaczl
<br /> ieoacicsis 'vas
<br /> n ecra v 4°obse rved� (^1924`) Y' W,,V
<br /> !
<br /> Lit ` rmmary
<br /> P dermal
<br /> mode rateLv , Lrritaclon tests " , titer numoer � oils were
<br /> trrztatiiz$_ while- Chea „ number °-6 o iLs^ Jere rnintmally Co
<br /> s1Lgh�iv .Lr`ritating. i?iesel fuel w vas extremely L'rritatLng. _ Signs
<br /> included severe e
<br /> rythema and ed 'ma vitt bliscerirt and 'open sates. The
<br /> tlSC Vasa Call ducted' 'bY�rapprLYln' !' 1 r+g
<br /> rabbit skxn'' �' $ O.5 mL ,of Ruitdzlueed material to'"abiadea
<br /> I * �, r p ,
<br /> !!, a Ce1s5t 41uaSijrChen cave red for,° �`uW�10lirs 'atfj fts.7f11ch p0 Lnt [i1@
<br /> bandage+: +Jas ;�remnverd'r and�aa��r;�e aatmils `6score'!a A�a� 'ac',,
<br /> ,which
<br /> J' h + ,r ccordLng, ca the Draize +�
<br /> , ,? r
<br /> a�y y1 ' f� i ! �, ' ,Tr'v ,r ' r vp.r^'!vn
<br /> j st t ^rty sw
<br /> i�i ._ ri _
<br /> The ntmber 6 'o'tIs%wece 'mLnlmally Cc r3 EZ LrrLcating +Jaen 0 1
<br /> zi. Jas applied co , rabbit zees y ^,
<br /> redness swelling and^ dlschar a These mare rials producea con3unctivaL �j
<br /> but a es •," 3 Fey corneal oQacLcies .ere produced
<br /> -eyes recurnedE� c°' +„nortnal,a
<br /> �+ + = ski , tehin , 72 hours I Diesel ' fue'1 'Jas
<br /> R°n- Lrr•,cacing and'jJnumberri 2`` otls ranged from practically non- irritating
<br /> co �tidly LrritatLng ( L5Z�)a ”
<br /> r 1'
<br /> +
<br /> q
<br /> 1
<br /> r „ j 6/$7
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