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-2c <br />, <br /> Z Ct==Lr_ ToZzc�r <br /> *In 51= were, intrad regarazr. -:a corc=c == a:.=7 of �.:cl oiLs <br /> 55.3.2 �,•••.,-. and �aidolcgzc Sees <br /> �, 66.3.2.1 ShQrc-terra Toxsr�iogic affects <br />�k The c3zief systemzc react:.= co pe=ole= hydrocarbons, sura as l _ <br /> °ate• is c$ntrai nervm= syr=am anpressiaa (17) _ Zoxicolagzczi <br /> eifaars .:re, esaeczad ro resemolQ dose of a lou oral. <br /> cO = deraai and hili# asPszazian hszm CL (IZ) . Provdea :ha= <br /> QspLraziaa does =ot occt=, -ch& mQ = oral le=3111 dose of kerosene for an <br /> air is eS%I=a=d to be 4 to 6 oche. Hawaver, tvz= rhos ammunt has <br /> been talarar.pd amd less thea ounce has caused dr-atd (17) . Tlats <br /> carinate mal• be lav since oral LD50 values is rars. r bbitz and guinea. <br /> P'93 Qx=ed 20 <br /> 24 hours mL.ncg_ I>z £sul poisooiags, dezca tray occur trashier 2 4a <br /> after roger=oa. The dif+aremca oe=aa n cases of emrammii- <br /> I� cased IMgestiaa and :.he leg-hzi dace crhase asazra=L= occur-" -..z4 or- as <br /> great as a pant cad a tessPoanftzl_ Yha char_ctersstzc leaxoa ressstsng <br /> iota aso =auan z.s as acute and often zaral broachcVneumcmma_ Kerosene <br /> and related hydroeazbons Sze 21,so ZZZ=z3g co the sriu and =mrL oux <br /> y� = maraaes. Fercur.—ecus absorprmon =my be sagc.fic=c (17) . <br /> Dari exposura ro die:sel nal has cauised nept=,c:osic,*_7. A mea <br /> who cicaaed his Hands and azms wlrh dim al oil over several vealts <br /> exPertaaced sytaatcros Of epigascx-tc and lain pain. Mhirs4. moccurxa, <br /> nausea, anorexia, scrarai svaliirg, severe exhausrion and pin==g ammicle <br />' edema. Rommal biopsy revealed ar�xr_e rah•}ar necrosis %rLrh patchy <br /> dagenerauoaz and necrosis of :he pro==wl and discal tibular apzshelium <br /> (1814). Acorher cera cram described by 3arrfeatos ec as Z. (1815) who <br /> =eporred aeura oliguric failure aa_a pazienr who had vasned his hair <br /> oath diesel oil. A renal biopsy pericrmed rhe next day showed pular <br /> dilaclou and a pro 3.i_ferauau Of cells za rhe glo=er u l i. S IM11ar <br /> :eph=ozeszc effacz.: vane reported as a result or ;-hmlazioa oz daesal <br /> ' oil vaQors in a kk cao over a 10 day peziod (1816) . <br /> Liauid 4eL=oieum hydrncarboas cause lira=te or ,o iZ3ury on dared <br /> eye conracz_ Kerosene aria net=oieum oil on ;zbbac .ana -:mar_ cor_:cas <br /> i are essentially innocuous (19) . <br /> i <br /> 66.3.2.2 Chronic Toxicologic Hffzcrs <br /> No scudies were found which evalua=ed the esieczs or long-cent <br /> exsosure ca fuel vzls. However. nt=ercum eoidemiologp szudzes <br /> evaluara.g the effec=s of pezralet= exposure nate oeen Conauc=ed. <br /> 'hale tcst have snovn overall sraUdzzdi=ed mort:.lity rac2.os co Qe lower <br /> ohne chose of rhe general papula=aa. elevated uumoerz of deachs have <br /> been oosezved for cancers at several sites_ dowever. these aievaz;arts <br /> are ^oz forma consisrznzrly .a all of tha stzsaLes_ Caucezz have been <br /> C� <br /> l <br /> 4/87 <br />