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66-2:
<br /> ,
<br /> oaserged LA the Lung, nasal cavity - ane suffuses. esClve
<br /> 5r= skin. ,Pancreas and kzdnev - di$ System, �
<br /> been reported (1817) Leuxi
<br /> emaz and 1vmphomas nave also
<br /> ob 3 3 Toxxcoto¢y of Fuel all Comaanencs
<br /> A brief overview oL'
<br /> caMManents ro=_fuel_otls_ Ctse " tnxi ---
<br /> calo¢y of the ma}or hydrocarbon — -
<br />- - ---- are-summarizad4belav(see Table 66-5)
<br /> v �
<br /> Hexane mav` be rhe most tiLghly -
<br /> Lngesced - toxic raemae r Yo f'w the^alkanes. Vhen
<br /> Lrriutionis3,causes .,nausea, vertigo, bronchjal`f and general Lnres�inal
<br /> a17d '�.S ex act.3 S ��, i° e.......4
<br /> hazard " �„ �/�CutE�Y a » ' '� IL n;also, presenCs YAan �acuce,''aSpiraLton
<br /> xposure yrr',occurs . primarx1y through ' L
<br /> ;ion=specxfic;'�s"` teras" a� t ' t Yr nhalaclan.
<br /> are sum'; ash ercigo, hesd'ache, natisei arsd vO�iting
<br /> the firs= to be"
<br /> e manifested. ,fie , High conc`enc'ratians.
<br /> zarcnsts- like ` state aopears as s resuir of I r,� aepresston1
<br /> °_e-narcotic svrapcoms. occur, ac vapor concencraetons ranging Eroia
<br /> LS00.2500 ppm: ri-Hexane - :��
<br /> A,re*, FLL`riZaCes eche eyes, and,,mucous. membranes
<br /> ,x thes,we.effwerr`c� cs� �'.carTML-a'rbr,tei`i,se� en-ma�f,�,t�.a-r"an-erx, po., su::e Fa,33 fyLu80' pF
<br /> m°,fo`
<br /> r 15 mL
<br /> nucas.Skin,,_conrac=. Causes—,faremava1 Inc,an7cutaneals° ,
<br /> LrrYltaLlOn.
<br /> ad.�»'ra
<br /> ,ChrCnLG'�@:L asure F to i
<br /> the EzrsC clitoral Ysi,V Fr,n'hexane vapors causes, peripherall` neurop'*chy-
<br /> rche' caes 11 and fingers., Bn'^sof° neural damage zs a° rfeeling oke numbness Ln
<br /> g 1, "Progression leads to furt:her,`sym:aee=ical'
<br /> LmgairmenC La`" the ?,dfSCal ` � V ,,. + , •, ' + sensory
<br /> r , ,'tr,I}/� ��3 parttons of the eXCremxr:fe`a- 'and cn' toss,
<br /> suscularE srreItchtngIw' of
<br /> xWeakness ' '' ` ;,� refZe!ces: r Vltimacely; f4, symmecrLcal'�°` m+sscular
<br /> develops' rj �� �� � � rs �,
<br /> Firal vis r ° •`,chiefly ,La the distal portion 'of the ;extramictes.
<br /> catkin y developsv,ich Varying ' 'de"re.es o£ � impaired grasping end
<br /> B. a'Lh is'�- �, 6 , 6
<br /> "' ruuscular< ',atropny: (sensortm�ocar
<br /> palvneurnpachv) The` ,, rdeveLopmenc o f eleccropnysiologxcsl changes
<br /> parallels rise severity"of the clinical pLccure In cine most severe
<br /> Lavas nerve concur=tvtCy is neutralized In same cases cranial nerve
<br /> _avaLve�aenc is also observed: After exposure ceasesjithecavery begins
<br /> ,rears 6 to , t0 :nova a Ln mild to moderate cases , but may caste uo to 3
<br /> ,rears Ln. serious cases. Iiia threshold level ac which neurovachv occurs
<br /> %as not rbeen fzrml'v established but sveesprorsss tsave been observed Ln
<br /> :eonle exposed [o concentrations rangLng f--cm 10 , co 200' ppm for u-L2
<br /> In animals , signs of narcosis are seen aFcer mice are eNnosed [a
<br /> „por Levels of 16"000 pptu-for 5 minutes
<br /> concentrations between 43 $00 and 52.000 Oeach generally occurred at
<br /> oral LO , 'is tired as '[. mL./k Ppm after 9- 1.19 mtnuces . The
<br /> loun¢ aYdult rats, 8 for L4-dav-o id' cars and y9 mL;l.g For
<br /> .r
<br /> t-Ong-Cerm inhalation experiments Ln rars suggest that the first
<br /> signs of neurat:axicicy appear after thev are exmosed to leve is of 200
<br /> ppn for 24 weeks This higher threshold to induce neurocoxicLcv to
<br /> animals may be aue co differences in metabolism- Specifically
<br /> 2-hexanol Ls the cnief metabolite in animals lntle 2 5 -hexaneaione
<br /> 6/87
<br />
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