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<br /> !L TlOMOTM GASOLINE k - 65-22
<br /> Tests for teracogeniczty induced 'bv the inhalation of unleaded
<br /> gasoline gave negative results. No additional details were reported
<br /> (2226)
<br /> 65.3 1.4 Other Toxicologic Effects,
<br /> 65-.3.1.4' 3: Shorr-Term Toxicz+ty`
<br /> - — - --Gasolines—,generally acc , as anescheti s.-'They, are also mucous
<br /> h 1 r, +Y l" t+ r
<br /> menbraae irritanis (2) . An oral-A4U.". sof 13.6 , g/,kgr was reported in the
<br /> rat for unleaded gasoline. + A 3single' dose of I8 g/kg produced 90%
<br /> mortality. '' I;A ,sigaifi'`caa`t %degree ,` oft g11
<br /> strointesr-Q'i ,,distress was
<br /> s x�T +q,s n 4 Aac F a• i
<br /> abaarbed, Necropsy, revealed ,`hemarrhagicr gastroenteritis, gastro-
<br /> ! j"A,Ft, �u 'ire
<br /> iatest3aal tym�paa�:'and,,pneumoni'a'ttwith`"abscess ,'formation,;{,1924)
<br /> �d
<br /> 1;,N
<br /> Acute' anesthetfic,,aandsVtoxic effects, of gasoline
<br /> asoline vaan>�po,�4'y r�I sS i +i`wer1'e studied tudied
<br /> °as;early as '16entrarl nervous systemteffects we,rerlobs+ erved; . r
<br /> J
<br /> ;
<br /> at approximately 10,000 ppm, and death at r about,,251,000 ;,ppm (229r0)`1
<br /> „ Toxicity } of',`xa,,, gasoline , component mzxture,�was evaluated in a
<br /> „short-,terminhal+"ationi,itudy.Perfcrmaddby Halder,eet ,al., `(2292) -1 'A ,blend
<br /> consisting of g 250�,"`�,(w/w)F� ,e y y �°`' m , „
<br /> yy�� ach o� n•butane n-pnittane. �i'sobutane and
<br /> SdR [i • 1 1 b! 5 F !1
<br /> Asopenta:ie- was' vaporized -'to.more closely approximate' ambient `exposure
<br /> ,a{pQr A tc Sita , , x {
<br /> C,ontrast yto complete 'ivolatilization) . i Etats�� exposed to° 44,,''432 or
<br /> 4437-1 ppm „of t,vapor for 6 hours par' day. 5` `days 'Ype +week for" 3 ,,weeks
<br /> shoxad„ iio clisiical�r}signs +}of of , distress. fNo gross, yor +histopathologic €
<br /> lesions ware noted,,- including, in, the kidneys,. -tAll "other parameters of
<br /> d f M 7 Y A} ,
<br /> body �<aiid ,°orgaa '�weighisk:+ „hematology or blood> '!chemistry ,were within
<br /> n .J '�� , Z F°� I,), w
<br /> 11
<br /> 0 ,range ��rY r ' �4 ¢¢"+1�, { h'E S it 5 fi ; A S
<br /> , Ygr,a i+�,F,j'6� ��w, , I,d�.���f }��r• ��� rty"4"i,k � ` f n�r4 ,r , h�`� �'+„{� F 1'�t f
<br /> rri a 1 f! a y , , � �
<br /> Studies s �onli�,thi�j'laeut$ ` 'effectsl F,of '14gasol'iiie ,ingestion by;, rats
<br /> 'revealed neplirotoxfcityr' rin Omale gats. Both iuzleaded"gasoline (2291)
<br /> rand shale-derived 7fuelf, (2294)1 caused reversible hyalIne
<br /> droplet formatioiYi�(prot'eir� resorption) in the, kidneys. This effect was
<br /> believed due , to a hydrocarbon-knduced defect in the degradation of
<br /> renal a.2 -globulin. a protesn` synthesized in the liver and excreted in
<br /> urine, aid was obvious after a single administration of as little as 2
<br /> mL,/kg gasoline -(27.91) . µ` dear a three day period, hepatic lesions and
<br /> alterations in, serum chemistry and hematology, Were noted. 3y fourteen
<br /> "days,' 'lymphoid depletion, in-,"the thymus was obseived, as was congestion
<br /> of multiple"organs, (2294) .
<br /> Y v .1 I I 4t, „ t
<br /> Unleaded motor gasoline was slightly irritating to the shaved skin
<br /> of New Zealand rabbits 'after a 24 hour dermal exposure to 0 5 mL. In a
<br /> subacute dermal. study, doses of 2.5 to 8 ml/kg were applied daily for a
<br /> total of '10 days. No mortality was seen. Severe dermal irritation and
<br /> ,weight loss were observed_ Necropsy revealed pale and congested livers
<br /> and kidneys (1924)
<br /> ` 'Gasoline concaining tetraethyl lead caused no more Ln3ury than
<br /> gasoline alone when applied to rabbit eyes. A single drop applied
<br /> without local anesthetic caused discomfort and blepharospasm lasting 1
<br /> 6/87
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