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�,�3TRMO'1Z4E GASOL= 65-23 <br /> several rninuz8s. The con]uacziva became mildly hppexemsc but rapidly <br /> rated to normal. Ton draps applied during a 5 za=ca per_- (after <br /> local anesthasia) caused blepharospasm Lasting 15 mu=te._ The <br /> cony—r-civa became moderately edematous and hyperemic but recc-- -v was <br /> ' promoc and complete (19) . <br /> 65.3.1.4.2 Chronic Toxicity <br /> To_ evaluate the long-term effects of_gasoline inhalation, rats and <br /> monkays were exposed to either 284 or 1552 ppm unleaded gasoline vapors <br /> or 103 and 374 ppm leaded gasoline vapor 6 hours per day. 5 days per <br /> weak. for 90 days (2290) . Although vomiting was noted in cartain <br /> monkeys azar 2 weeks exposure. no refs-rkable cbaages in body weigh=, <br /> hematology, or CNS responses were noted in either species. Lead <br /> deposition is the liver, kidney, brain and blood ware observed in those <br /> anima Ia eraatad with leaded gasoline. Upon histopathologic <br /> examiasrion, male rats exposed to 1552 ppm unleaded gasoline displayed <br /> regenerativa epxthalium and dilated tubules in the kidney <br /> Pulmonary changes in rats exposed to leaded gasoline vapor ware <br /> reviewed by Cooper (2296) . Changes in wale rats ranged from minor fact <br /> of interstitial fibrosis to widespread sclerosis after 6 weeks exposure <br /> to 100 ppm. After eight weeks, cachypnea and prostration were evident. <br /> Such obzarvacions were confirmed in female rats similarly exposed. <br /> Ultrastructural changes enarged sequentially as dageneracion. <br /> hypertrophy and/or hyperplasia and finally development of interstitial <br /> sclerosis and irregular alveolar collapse. A inmtbar of these diet a <br /> are thought related to the fact that gasoline vapor inhalation cauuad a <br /> docreaga in pulmonary surfactant. Surfactant. functioning to dscroaan <br /> surfacra cransion and seabiliza surfac a forces, waa reduced after only 5 <br /> 1} days euposurs. <br /> Ropeacad exposure of albino rabbits eyes to gasoline vapor 1mvols <br /> of 3 mg/L air daily for 10 months has been reported to cause <br /> histoiogzcally -recognizable disturbances of the corneal and <br /> { eoa3unctival epithelium. Exposure to a vapor level of 616 ppm of a <br /> Cl-Cie fraction of a high oetaae motor fuel induced cataracts in 70# of <br /> exposed rats. Exposure was for a total of 2424 hours. The pecrolaua <br /> fraction was composed mainly of alkyl benzenes. It contained no <br /> naphthalene. a known inducer of cataracts in an mnla (19) <br /> Other changes seen in animals after chronic gasoline inhalation <br /> include a depression in body weight in rats and mice, a reduction in <br /> !- the iaczdence of cystic or enlarged uteri of female mica. and mild <br /> multifocal, dose-related pulmonary inflammation in rats (2296) . <br /> 63.3.2 Huma;m and Epidemiologic Studies <br /> Before reviewing the adverse effects of gasoline on humans. it is <br /> importaxzr to noce chat human exposure is considerably different from <br /> �- that used in animal studies. Due to the differential volatility of the <br /> hydrocarbon compounds present in gasoline. the vapor produced Under <br /> 5 <br /> 6/87 <br />