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'uTOHOTIVE t,ASOLI:.E , r <br /> _0 months in mild to moderate 'cases out Wav take un t6 '3 vears <br /> serious cases. The chresnold Ievei at wnich neuropathv occurs has ,not M' <br /> been firmly estaolished but symptoms have been observes "in peoD�e <br /> exposed to concentrations ranging from l0 to 200 ppm for 9-12 months <br /> In animals. signs of narcosis are seen after mice are exposes to <br /> raDor levels of 16,000 ppm for 5 minutes 0eatn generally occurred at <br /> concentrations between 43,800 and 52,000 ppm, after -9-119 minutes -7he <br /> oral LDS, 'is cited as -24 mL/kg -=or l4-dayf-olds rays and 49 mL/kg, for , <br /> young adult rats'. " <br /> 1� f <br /> _- __. ___ __ - •1� -_-- <br /> Long-term inhalation experiments" in; ra"c""'u est that the ' first <br /> p gg <br /> sLgns of neurotoxicity appear `after they ' aretF exposed to levels of 200 <br /> ppm for, 24 wee". This higher threshold to%' induce neurocoxicity in <br /> anLmais may be ' due to differences in me[abolism. Specifically, <br /> 2-hexanol is , the, chief, metabolite in animals. while' 2,'S-hexanedione•<t <br /> which is neurozoxLc.''I predomanates��int"man: ,,,?Chronic <br /> � " <br /> si1topical , application <br /> of a solvent containing 35 2B' n-hekane,„, ca'used ' axonal, swelling and <br /> myeiin degeneration- in,,,chicks: <br />