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' caused by hexane. The oral LZLa in rabbits ranges from 5 .5 to 6 .0 <br /> g/1cg. Within 1.5 hours the antva-mtc exhibitad severe diarrhea. <br /> widespread vascular damage aztd collapse. Degenerative Lesions were <br /> seen in the heazz, lung, liver. kidney and bras.n. A one-nour vapor <br /> exposure to 26,752 ppm caused rapid narcosis and tremor and was Lethal <br /> co all exposed rabbits. In mica. concentrations causing narcosis vary <br /> from 14.600 to 122.000 ppm. <br /> Cyclohexane is nominally absorbed c3irougq the skis aithouga <br /> massive applications (>180.Z g/kg) cc rabbit skin resulted zn <br /> -" microscopic changes in the liver and kidneys and caused the death of <br /> all animals. <br />{ The danger of chronic poisoning is relatively slight because this <br />+� compound is almost completely eliminated from the body. No ccxic <br /> changes ware seen in rabbits exposed to vapor levels of 434 ppm, 6 <br /> hours daily for 50 exposures. but some microscopic changes were seen in <br /> the liver and kidneys when the exposure was to 786 ppm for the same <br /> periad. <br /> In man. no systemic poisonings by cyclohexane have bean reported. <br /> A vapor level of 300 Qpm is somewnac irritating to the eyes and mucous <br /> membranes. It has been reported chat cyclohexane may potentiate the <br /> toxic effects of TOCP but no additional details of this interaction are <br /> available (12,17,46.54,1937) <br /> RenZeng <br /> The primacy effects of bnnzeno inhalation and ingestion are on the <br /> E central norvous system (54) . Bonzeno is carcinogenic in both animals <br /> and man. Soveral reports have established a relationship botva(an <br />' bonzenra exposure and leukemia. For more Lnformacion. refer to Chapter <br /> 13 of the Installation ResccratLon Program Toxicology Guide, Volume L. <br /> h� Toluene <br /> Toluene is a CHS depressant with a low coxicLty For more <br /> Information, refer cc Chapter 19 of the Installation Restoration <br /> Program Toxicology Guide. Volume 1. <br /> E Xvlenes <br /> Acute exposure cc high concentrations of xylene vapors may cause <br /> CBS depression., Both the liquid and the vapor are irritating to the <br /> eyes, mucous membranes and skin (46) . The National Toxicology Program <br />' E recently reported that there was no evidence of carcinogenicity of <br />+ mixed xylenes in either mice or rats given daily dozes ranging from 250 <br /> cc 1000 mg/kg by gavage for 2 years (1939) . <br /> For more information. refer to Chapter 21 of the Installation <br />` Restoration Program Toxicology Guide. Volume 1. <br /> 6/87 <br /> E <br /> �Y <br />