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r, <br /> product Name : Gasoline with Ethanol page 11 of 15 <br /> roduct Code• Multiple <br /> characterized by the accumulation of alpha---2--u- globulin in <br /> epithelial cells of the proximal tubules, and necrosis and <br /> hyperplasia of surrounding cells . Follow-up studies have <br /> demonstrated that these changes are unique to the male rat . <br /> Although prolonged exposure to n-hexane, a component of <br /> gasoline, has resulted in adverse male reproductive effects in <br /> experimental animal studies, no adverse male reproductive <br /> effects were found in studies conducted with gasoline <br /> Developmental: No evidence of developmental toxicity was found in <br /> pregnant laboratory animals (rats and mice) exposed to up to <br /> 9, 000 ppm vapor of unleaded gasoline via inhalation <br /> Xylenes (CAS# 3330-20-7) <br /> Target Organ (s) • A six week inhalation study with xylene produced <br /> hearing loss in rats . <br /> Developmental : Both mixed xylenes and the individual isomers <br /> produced limited evidence of developmental toxicity in <br /> laboratory animals . Inhalation and oral administration of <br /> xylene resulted in decreased fetal weight, increased incidences <br /> of delayed ossification, skeletal variations and resorptions . <br /> Ethanol (CAS# 64-17-5) <br /> Carcinogenscity: Ingestion of alcoholic beverages has been <br /> classified by IARC as "carcinogenic to humans" (Group 1) _ <br /> Occupational exposures to ethanol and exposures other than by <br /> ingestion (i . e . , dermal and inhalation) have not been associated <br /> with cancer in humans . <br /> Target Organ (s) Chronic alcoholism has been associated with damage <br /> to the liver in humans (e. g. , cirrhosis of the liver) <br /> Excessive consumption of alcoholic beverages has also been <br /> associated with adverse effects on the central nervous system, <br /> digestive system, cardiovascular system, and the reproductive <br /> system including reduced sperm count and motility and loss of <br /> libido in men, abnormal menstrual function, and decreased plasma <br /> estradiol and progesterone levels in women. <br /> Developmental: Excessive consumption of alcoholic beverages during <br /> pregnancy has been associated with effects on the developing <br /> fetus referred to collectively as the fetal alcohol syndrome . <br /> The effects most frequently manifested include psychomotor <br /> dysfunction, growth retardation and a characteristic cluster of <br /> facial anomalies. <br /> Issue Date : 03/29/99 Status : Final Revised <br /> Revised Sections • 1, 2, 3, 4 , 5, 6, 7, $ , 9, 11, 14 <br />