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f <br /> Product Name- Gasoline with Ethanol page 12 of 15 • <br /> Product Code - Multiple <br /> Mutagenicity- Excessive consumption of alcoholic beverages has been <br /> associated with chromosomal aberrations in white blood cells . <br /> Depending on the animal species being tested, ethanol may <br /> produce chromosomal damage, DNA damage and mutation in both <br /> somatic and germ cells <br /> Toluene (CAS# 108-8$-3) <br /> Target Organ (s) : Epidemiology studies suggest that chronic <br /> occupational overexposure to toluene may damage color vision- <br /> Subchronic and chronic inhalation studies with toluene produced <br /> kidney and liver damage, hearing loss and central nervous system <br /> (brain) damage in laboratory animas . Intentional misuse by <br /> deliberate inhalation of high concentrations of toluene has been <br /> shown to cause liver, kidney, and central nervous system damage, <br /> including hearing loss and visual disturbances . <br /> Developmental Exposure to toluene during pregnancy has <br /> demonstrated limited evidence of developmental toxicity in <br /> laboratory animals The effects seen include decreased fetal <br /> body weight and increased skeletal variations in both inhalation ) <br /> and oral studies . <br /> Ethyl. Benzene (CAS# 100-41-4) <br /> Carcinogenicity: Rats and mice exposed to 0, 75, 250, or 750 ppm <br /> ethyl benzene in a two year inhalation study demonstrated <br /> limited evidence of kidney, liver, and lung cancer Ethyl <br /> benzene has not been listed as a carcinogen by NTP, IARC, or <br /> OSHA <br /> Target Organ (s) , In rats and mice exposed to 0, 75, 250, or 750 ppm <br /> ethyl benzene in a two year inhalation study there was mild <br /> damage to the kidney (tubular hyperplasia) , liver (eosinophilio <br /> foci, hypertrophy, necrosis) , thyroid (hyperplasia) and <br /> pituitary (hyperplasia) <br /> n-Hexane (CAS# 110-54-3) -- <br /> Target Organ (s) Excessive exposure to n-hexane can result in <br /> peripheral neuropathies The initial symptoms are symmetrical <br /> sensory numbness and paresthesias of distal portions of the <br /> extremities . Motor weakness is typically observed in muscles of <br /> the toes and fingers but may also involve muscles of the arms, <br /> thighs and forearms . The onset of these symptoms may be <br /> delayed for several months to a year after the beginning of <br /> exposure . The neurotoxic properties of n--hexane are potentiated . <br /> by exposure to methyl ethyl ketone and methyl isobutyl ketone <br /> Issue Date: 03/29/99 Status . Final Revised <br /> Revised Sections 1, 2, 3, 4 , 5, 6, 7 , 8, 9, 11, 14 <br />