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EXTOXNET Extension Toxicology Network Pesticide Information Profiles A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the University of Idaho, and the University of California at Davis and the Institute for Environmental Toxicology, Michigan State University. Major support and funding was provided by the USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program. EXTOXNET primary files maintained and archived at Oregon State University Revised June 1996 Trifluralin Trade and Other Names: Trade names include Crisalin, Elancolan, Flurene SE, Ipersan, L-36352, M.T.F., Su Seguro Carpidor, TR-10, Trefanocide, Treficon, Treflan, Tri-4, Trifluralina 600, Triflurex Trim, and Trust. The compound may be found in formulations with other herbicides. Regulatory Status: Products containing trifluralin bear the Signal Words CAUTION or WARNING, depending on the type of formulation. This compound is a General Use Pesticide (GUP) in toxicity class III - slightly toxic.N-nitrosamine contaminant levels in trifluralin are required to be below 0.5 ppm, a level which EPA believes will result in no toxic effects. Chemical Class: dinitroaniline compound Introduction: Trifluralin is a selective, pre-emergence dinitroaniline herbicide used to control many annual grasses and broadleaf weeds in a large variety of tree fruit, nut, vegetable, and grain crops, including soybeans, sunflowers, cotton, and alfalfa. Pre-emergence herbicides are applied before weed seedlings sprout. Trifluralin should be incorporated into the soil by mechanical means within 24 hours of application. Granular formulations may be incorporated by overhead irrigation. Trifluralin is available in granular and emulsifiable concentrate formulations. The technical material is approximately 96% pure and the emulsifiable concentrate is about 45%pure. Formulation: Granular formulations may be incorporated by overhead irrigation. Trifluralin is available in granular and emulsifiable concentrate formulations. The technical material is approximately 96%pure and the emulsifiable concentrate is about 45%pure. Toxicological Effects: • Acute toxicity: Pure trifluralin is practically nontoxic to test animals by oral, dermal, or inhalation routes of exposure [138]. The oral LD50 for technical trifluralin in rats is greater than 10,000 mg/kg, in mice is eater than 5 000 mg/kg, and in dogs, rabbits and � g , chickens, is greater than 2000 mg/kg. However, certain formulated products that contain trifluralin may p be more Y toxic than the technical material itself. For example,the oral LD50 for Treflan TR-10 in rats is