|
CHMON Regular Gaicline page Z of 10
<br /> P-XYLENE(l,4-DIMETHYL BENZENEI 01,02,10,11,26,28,
<br /> M-XYLENE 01,02,10,11,14,15,17,18,26,26,
<br /> TOLUENE 01,02,10,1; ,14,1;.,17,18.26,28,
<br /> HEXANE 02,10.11,14,17,28,
<br /> CYCLOHEXANE 01,02,10,11,14,17,26*,28,
<br /> METHYL TERT BUTYL ETHER 01,10,11,24,26,
<br /> BENZENE 01,02,03,04,06,10,11,14,17,18,20,28,
<br /> TETRAETHYLLEAD 02,:10,11,14,17,28,
<br /> O-XYLENE(1,2-DIMETHYL BENZENE) 01,02,10,11,14,15,17,18,26,28,
<br /> GASOLINE (GENERIC) 04,08,14,15,17,18,20,
<br /> REGULATORY LISTS:
<br /> 01=SARA 313 02-MASS RTK 03-NTP Carcinogen
<br /> 041-CA Prop. 65 05-M1 406 06=IARC Group 1 M
<br /> 07-IARC Group 2A 08-IARC Group 2B 09=SARA 302/30.1
<br /> 10-PA RTK 11-NJ RTK 12-CERCLA 302.4
<br /> 13-MN RTK 14uACGIH TLV 15-ACGIH STEL
<br /> 16-ACGIH Calculated TLV 17=OSHA PEL 18-OSHA STEL
<br /> 19-Chevron TLV 20eEPA Carcinogen 21=TSCA SECT 4
<br /> 22-TSCA SECT 5 SNUR 23eTSCA SECT 6 RULE 24-TSCA SECT 12 EXPORT
<br /> 25-TSCA SECT 8A CAIR 26-TSCA SECT 8D REPORT 27-TSCA SECT 81:
<br /> 28-Canadian WHMIS
<br /> 11. PRODUCT TOXICOLOGY DATA
<br /> EYE IRRIZATION:
<br /> NDA. The hazard evaluation was based on data from similar materials.
<br /> SKIN IRRITATION:
<br /> This material Was not a skin sensitizer in the modified Buehler Guinea Pig
<br /> Sensitization Test.
<br /> DERMAL TOXICITY:
<br /> NDA. The hazard evaluation was based on data from similar mat-srials.
<br /> RESPIRATORY/INHALATION:
<br /> NDA. The hazard evaluation was based on data from similar materials.
<br /> INGESTION:
<br /> NDA. The hazard evaluation was based on data from similar materials.
<br /> ADDITIONAL TOXICOLOGY DATA:
<br /> Lifetime inhalation of whole gasoline vapor has caused increased liver
<br /> tumors in female mice. The mechanism of this response is still being
<br /> investigated but it is thought to be an epigenetic process unique to the
<br /> female mouse. Inhalation exposure to whole gasoline vapor also caused
<br /> kidney damage and eventually kidney cancer in male rats.
<br /> No other animal model studied has shown these adverse kidney effects and
<br /> there is no physiological reason to believe that they would occur in man.
<br /> The cause of the kidney toxicity is thought to be due to the interaction
<br /> of isoparaffin hydrocarbons in the product with a specific serum protein,
<br /> alpha-2-microglobulin. Male rats synthesis large amounts of this protein
<br /> which is filtered, reabsorbed, and degraded by their kidneys.
<br /> Isoparaffins or their metabolites combine with this protein and make it
<br /> "undigestable" by the kidney proteases. With repeated exposure, the
<br /> Revision NumbeG: 13 Revision Date: 03124/90 MSDS Number: 0003363
<br /> NDA - No Data Available AIA - Not Applicable
<br />
|