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iI. 55 .try ilyi <br /> ' irVli"'li 1151 i il <br /> 'i d�iugtsm , <br /> CHEVRON Supreme Unieaded Gasoline Page 8 of 10 <br /> 04=CA Prop. 65 05-MI 406 06-IARC Group 1 <br /> 07=IARC Group 2A OB-IARC Group 2B 09aSARA 302/304 <br /> 10=PP RTA 11-N3 RTIC 12-CERCLA 302.4 -� <br /> 13=MN RTK 14-ACGIN TLV 15-At'GIH STEL <br /> 16-ACGIH Calculated TLV 17-OSTIA PEL 18-OSHA STEL <br /> 19=Chevron TLV 20-EPR Carcinogen 21-TSCA SECT 4 <br /> 22-TSCA SECT.5 SNUR 23-TSCA SECT 6 RULE 24-TSCA SECT 12 EXPORT <br /> 25-TSCA SECT BA CAIR 26=TSCA SECT 8D REPORT 27-TSCA SECT 8E W. <br /> 28-Canadian wHMIS <br /> �a <br /> 11. PRODUCT TOXICOLOGY DATA ; <br /> EYE IRRITATION: <br /> The Draize Eye Irritation Score (range, 0-110) in rabbits is 0. <br /> STUN IRRITATION: <br /> The Draize Skin Primary Irritation Score (range, 0-8) for a 4-hour <br /> Exposure (rabbits) is 0.98. This material was not a skin sensitizer in <br /> the modified Buehler Guinea Pig Sensitization Test. <br /> DERMAL TOXICITY: <br /> The dermal LD50 in rabbits is > e ml/kg. <br /> RESPIRATORY/INHALATION: <br /> NDA. <br /> INGESTION: <br /> The oral LD50 in rats is > 5 ml/kg. <br /> ADDITIONAL TOXICOLOGY DATA: <br /> Lifetime inhalation of whole gasoline vapor has caused increased liver <br /> tumors in female mice. The mechanism of this response is still being f <br /> investigated but it is thought to be an epigenetic process unique to the <br /> female mouse. Inhalation exposure to whole gasoline vapor also caused <br /> kidney damage and eventually kidney canner in male rats. <br /> No other animal model studied has shown these adverse kidney effects and <br /> there is no physiological reason to believe that they would occur in man. <br /> The cause of the kidney toxicity is thought to be due to the interaction <br /> of isoparaffin hydrocarbons in the product with a specific serum protein, <br /> alpha-2-microglobulin. Male rats synthesis large amounts of this protein <br /> which is filtered, reabsorbed, and degraded by their kidneys. <br /> Isopa=affins or their metabolites combine with this protein and make it. <br /> "undigestable" by the kidney proteases. with repeated exposure, the <br /> protein-isoparaffin complex accumulates in the kidney tubules causing <br /> significant cell death and regrowth. It is thought that this continuous <br /> kidney injury may contribute to the eventual development of the tumors. <br /> The data above isiobtained from studies sponsored by the American µ <br /> Petroleum Institute (API). <br /> 12. ADDITIONAL REALTU DATA <br /> ADDITIONAL HEALTH DATA COMMENT: <br /> This product contains benzene. The OSHA Benzene Standard (29 CFR <br /> Revision Number: 13 Revision Date: 03/24/90 ILSDS Number: 001376 <br /> NDA - No Data Available NA - Not Applicable <br />