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..I�........... lr,lo„ CHEVRON Supreme Unle' aded Gasoline Page 9 of 10 1910.1026) contains detailed rec:uireme:' for training, expo:•ure monitoring, res,ji-atory protection and %dical surveillance triggered by the exposure level. Refer to the OSHA S..;7dard before using this product. Repeated or prolonged breathing of benzeLe vaNbrs has been associated with the development of chromosomal damage in experimental animals and various blood diseases in humans ranging from aplastic anemia to leukemia (a, form of cancer). All of these diseases can be fatal. No birth defects have been shown to occur in pregnant laboratory animals exposed to doses not toxic to the mother. However, some evidence of fetal toxicity such as delayed physical development has been seen at such levels. The available information on the effects of benzene on human pregnancigrs i--• inadequate but it has been established that benzene can cross the human placenta. This product contains. n-hexane. Prolonged or repeated skin contact or breathing of vapors may cause nerve damage characterized by progressive weakness and numbness in the arms and legs. Recovery ranges from no recovery to complete recovery depending upon the severity of the nerve damage. This product contains toluene. Toluene has peen reported to cecrease immunological responses in test animals. It has also been reported that when young rats were exposed to 1000 ppm toluene for 14 hours daily, for two weeks, irreversible hearing loss was detected. The same Gaily exposure to 700 ppm for as long as 16 weeks was without effect. Since the level necessary to produce hearing loss is greater than 7 times the 1987-88 ACGIH TLV for toluene, worker exposures at or below 100 ppm is not expected to cause any adverse effect. There are also reports that chronic abuser:; (glue sniffers, solvent huffers) of solvents containing toluene have suffered liver, kidney and brain damage. Scientific studies on toluene have failed to demonstrate birth defects in rats and mice. However, toluene has been shown to cause delayed growth and extra ribs in the of6spring of rats and mice at inhaled doses (266-399 ppm) that were non-toxic to the mother. Toluene has not conclusively been shown to cause adverse reproductive effects in humans. This product contains xylene, a chemical that has been reported to cause developmental toxicity in rats and mice exposed by inhalation during pregnancy. The effects noted consisted of delayed development and minor skeletal variations; additionally, when pregnant mice were exposed by ingestion to a level that killed nearly one-third of the test group, lethality (resorptions) and malformations (primarily cleft palate) occurred. Malformations have not been reported following inhalation exposure. Because of the very high levels of exposure used in these studies, we do not believe that their results imply an increased risk of reproductive toxicity to workers exposed to xylene levels at or below the exposure standard. Xylene has given negative results in several mutagen testing assays including the Ames assay. In a cancer study sponsored by the National Toxicology Program, (NTP) , technical grade xylene gave no evidence of carcinogenicity in rats or mice dosed daily for two years. Whole gasoline exhaust was reviewed by the international Agency for Research on Cancer (IARC) in their Monograph Volume 46 (1989)- Evidence Revision Huaber: 13 Revision Date: 03/24/90 MSD5 number: 001376 HDA - No Data Available NA - Not Applicable I