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Human Health Risk Assessment <br /> Former Mobil Oil Bulk Plant 04-343 <br /> 500 East Grant Line Road <br /> Tracy, California <br /> Which symptoms can be attributed� ted to gasoline and which can be attrit,.;ted to additives such as <br /> lead and n-hexane. <br /> Liquid gasolines are considered to be skin irritants (Beck et al., 1982;. Prolonged or repeated <br /> contact with liquid gasoline may cause defatting and fissuring of tie skin and dermatitis. <br /> � Ab <br />€ sorption through the skin is likely but probably insufficient tc. cause direct systemic <br /> intoxication, except in extreme cases (API, 1980; Jakobson et al., 1982. McDougal et al., 1986). <br /> Additives such as tetraethyl lead can be readily absorbed through the skin with continued <br /> contact. Dermal contact with vapors would not be expected to cause skin irritation, although <br /> ' some individuals may be hypersensitive to vapor (Amorati et al., 195 ). <br /> ' Diesel <br /> ' The effects of acute exposure to diesel fuel have been reported. Tl,c. following information <br /> summarizes the data available regarding acute human exposure to di-sel fuel that Barrientos <br /> (1977) reported. Symptoms of intoxication, anuria, renal failure, arc gastrointestinal distress <br /> developed in a man using diesel fuel as a shampoo. A renal biopsy pr formed after the second <br /> day of exposure demonstrated tubular dilations with casts, flattening of epithelia cells, and <br /> ' vacuolization (Barrientos et al., 1977). Crisp (1979) described an in,. dent of renal failure in <br /> an adult male who had used diesel fuel as a hand cleaner for several weeks. A renal biopsy <br /> ' demonstrated acute tubular damage, degeneration, and necrosis of the pi.,ximal and distal tubular <br /> epithelium (Crisp et al., 1979). In a suicide attempt, a young woman ingested 1.5 liters of <br /> diesel fuel and developed a toxic lung disease and fever, which was rd.-;,.lved over a four month <br /> ' period (Boudet et al., 1983). <br /> ' 3.1.4.2 Carcinogenic Response in Humans <br /> ' Gasoline <br /> Epidemiological studies on humans have been inconsistent and unable to either support or refute <br /> any association between gasoline exposure and renal carcinomas (]McLaughlin et al., 1985; <br /> Harrington, 1987; Brownson, 1988). For the general population. the risk level is helieved to <br /> 30-0136-11 <br />�` ' 3-5 <br />