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Human Health Risk Assessment <br /> Former Mobil Oil Bulk Plant 04-343 <br /> 500 East Grant Line Road <br /> Tracy, California <br /> be negligible and cannot be g measured suitably by epidemiology(Cole, 1' 84). However, Thomas <br /> et al., (1982) found a significant increase in cancer of the stomach ad brain in workers in a <br /> Texas oil refinery. There was also an increase in the incidence of leukemia as well as cancers <br /> Of the pancreas, skin, and prostate. Hanis et al., (1982) were un <br /> elevation in any cancer standard mortality ratio (SMR) in a Baton Rouge unable to find a significant <br /> f I,e refinery. <br /> i <br /> ' Diesel <br /> IARC (1989) evaluated diesel fuels and concluded that there is inadequate evidence for <br /> carcinogenicity in humans. IARC has classified marine diesel ')bel (No.4) as possibly <br /> carcinogenic to humans and distillate (light) diesel fuels (No.'s 1 and 2) are not classified <br /> ' their carcinogenicity to humans. An epidemiology study was conducted by Siemiat cki et oto <br /> (1987) which examined the associations between cancer cases and expr Bare to twelve petroleum <br /> ' derived liquids. The Siemiatycki study concluded moderate to strcn statistical associations <br /> with: 1) stomach cancer with gasoline, kerosene and hydraulic fluids; 2) lung (oat cell) cancer <br /> with heating oil, 3) prostate cancer with mineral spirits and diesel fue'. 4) kidney cancer with <br /> aviation gasoline and jet fuel, and 5) rectal ands squamous amous cell Iung cancers with crude oil. <br /> E <br /> ' 3.1.5 Animal Toxicity Studies <br /> Gasoline <br /> Animal testing did not produce any compound-related effects in sperm Lnunt or quality, fetal sex <br /> ' ratio, embryotoxicity, fetal growth and development, or <br /> P teratogenic potential (API, 1978). <br /> Disturbances in the ovulatory cycle have been reported in women or(;upationally exposed to <br /> gasoline vapors (Mirinski et al., 1979; Feller, 1972). Two retarded children were born to <br /> mothers who lived in a community known to practice gasoline sniffing (Hunter et al., 1979). <br /> Unleadedasoline tested ed negative to all in vitro and in vivo assays C:nimonly used to test for <br /> ' mutagenicity and cytogenetic toxicity (Lebowitz et al., 1979). Unle-Jed gasoline (PS-6) was <br /> unable to induce unscheduled and replicative DNA synthesis in the mal,: rat kidney at levels that <br /> 30-0136-11 <br /> 3-6 <br />