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Human Health Risk Assessment <br /> Former Mobil Oil Bulk Plant 04-343 <br /> 500 East Grant Line Road <br /> Tracy, California <br /> had been shown to be nephrotoxic. Similarldoses administered b <br /> Y� y lavage were also negative <br /> (Loury et al., 1987). <br /> Along with the toxicity associated with light hydrocarbon nephropathy. the American Petroleum <br /> ' Institute's 2-year inhalation study on PS-6 gasoline also found microscopic kidney tumors o <br /> in the male rats. No neoplasms were found in the control (Scala, 198tumors fou�y <br /> 0. Of the <br /> r nd, <br /> ' ll were cancerous (carcinomas and sarcomas) and 3 were benign (aaenomas); the size of the <br /> tumors was not dose related. A pulmonary inflammatory response, failure to gain weight and <br /> i ' a statistical increase in hepatocellular carcinomas in female mice, were found only at the highest <br /> dose (2,056 ppm). The increased liver cancer did not occur in male m i-_a or male or female rats <br /> (MacFarland, 1982). <br /> ` 1 <br /> Diesel Fuel <br /> ' Acute toxicitystudies <br /> on animals demonstrated a low acute toxicity u. diesel fuel and similar <br /> petroleum-derived fractions. In one study, male and female B6C3F1 i-nice were dosed dermally <br /> with 2,000 to 40,000 mg/kg of marine diesel fuel for 14 consecutive days (NTP, 1986). <br /> Treatment groups of greater than 20,000 mg/kg displayed 100x= mortality. The mice <br /> ' demonstrated skin lesions which generally included acanthosis, parake! tosis, and inflammatory <br /> infiltrates in the dermis (NTP, 1986). No treatment-related mortaliay was observed in mice <br /> administered 250 to 4,000 mg/kg marine diesel fuel via dermal application 5 days/week for 13 <br /> weeks. The 4,000 mg/kg dose group exhibited a chronic dermatitis at the site of application. <br /> A study conducted by Chu et al., (1959) exposed rats to aerosols of materials from oils <br /> at 100 mg/m3, 6 hours/day, 5 days/week, for 4 weeks. N sands <br /> No adverse health effects were observed <br /> in the exposed group. <br /> 1 <br /> 3.1.6 Gasoline Additives <br /> ' The concentration of additives is regarded as being too low to significantly affect the acute <br /> ' toxicity of gasoline (Gerarde, 1962). However, to provide a complete c•verview of the potential <br /> toxicity of gasoline constituents information regarding gasoline additives is provided. <br /> 30-0136-11 <br /> 3-7 <br /> 1 <br />