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CITRON Unleaded Gasoline Page 8 of SO <br /> 07+IARC Group 2A 08-JARC Group 2B 09-SARA 302/304 <br /> 10-PA RTK 11-NJ RTK 12-CERCLA 302.4 <br /> 13+MN RTK 14-ACGIH TLV 15wACGIH STET. <br /> 16-ACGIH Calculated TLV 17-OSHA PEL 1BwOSHA STEL <br /> 19-Chevron TLV 20-EPA Carcinogen 21-TSCA SECT 4 <br /> 22-TSCA SECT 5 SNUR 23-TSCA SECT 6 RULE 24-TSCA SECT 12 EXPORT <br /> _ 25-TSCA SECT BA CAIR 26-TSCA SECT BD REPORT 27-TSCA SECT BE <br /> 28-Canadian WHMIS <br /> 11. PRODUCT TOXICOLOGIC DATA � <br /> {EYE IRRITATION: <br /> The Draize Eye Irritation Scare (range, 0-110) in rabbits is 0. <br /> SKIN IRRITATION: <br /> The Draize Skin Primary Irritation Score (range, 078) for a 4-hour <br /> exposure (rabbits) is 0.98. This material was )lot a skin sensitizer in <br /> the modified Buehler Guinea Pig Sensitization Test. <br /> DERMAL TOXICITY: <br /> The dermal LD50 in rabbits is > 5 ml/kg. <br /> RESPIRATORY/INHALATION: <br /> NDA. <br /> INGESTION: <br /> The oral LD50 in rats is > 5 ml/kg. <br /> ADDITIONAL TOXICOLOGY DATA: <br /> Lifetime inhalation of whole gasoline vapor has caused increased liver. <br /> tumors in female mice. The mechanise: of this response is still being <br /> investigated but it is thought to be an epigenetic process unique to the <br /> `-' female mouse. Inhalation exposure to whole gasoline vapor also caused <br /> kidney damage and eventually kidney cancer in male rats. <br /> No other animal model studied has shown these adverse kidney effects and <br /> there is no physiological reason to believe that they would occur in man. <br /> The cause of the kidney toxicity is thought to be due to the interaction <br /> of isoaaraffin hydrocarbons in the product with a specific serum protein, <br /> alpha-2-microglobulin. Male rats synthesis large amounts of this protein <br /> which is filtered, reabsorbed, and degraded by their kidneys. <br /> _ 3soparaffins or their metabolites combine with this protein and make it <br /> "undigestable" by the kidney proteases. With repeated exposure, the <br /> protein-isoparaffin complex accumulates in the kidney tubules causing <br /> significant cell death and regrowth. It is thought that this continuous <br /> kidney injury may contribute to the eventual development of the tumors,. <br /> The data above is obtained from studies sponsored by the American <br /> Petroleum Institute (AP3). <br /> 32. ADDITIONAL HEALTH DATA <br /> - - - <br /> hDD1TIQNAL-_HEIiLTH-DATA COMMENT: <br /> T This product contains benzene. The OSHA Benzene Standard (29 CFR <br /> 1910.1028) contains detailed requirements for training, exposure. <br /> Revision Number: 12 Revision Date: 03/24/90 msDs Number: 000372 <br /> NDA _ No Data Available NA - Net Applicable <br />