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, <br /> Page 9 of 10 <br /> ,m mm unleadad Gasoline <br /> monitoring, respiratory protection and medical surveillance triggered by <br /> P Y <br /> _he exposure level. Refer to the OSHA Standard before using this product. <br /> tepeated or prolonged breathing of benzenf• vapors has been assuciated with <br /> f chromosomal damage in experimental animals and various <br /> the development o <br /> alood diseases in humans ranging from aplastic anemia to leukemia {a form <br /> of cancer). All of these diseases can be fatal. No birth defects have <br /> aeen shown to occur in pregnant laboratory anima's exposed to.doses not <br /> toxic to the mother. However, some evidence of fetal toxicity such as <br /> delayed physical development has been seen at such levels. The available <br /> information on the effects of benzene on human pregnancies is inadequate <br /> but it has been established that benzene can cross the human placenta. <br /> This product contains n-hexane. Prolonged or repeated skin contact or <br /> breathing of vapors may cause nerve damage characterized by progressive <br /> weakness and numbness in the arms and legs. Recovery ranges from no <br /> recovery to complete recovery depending upon the severity of the nerve <br /> damage. <br /> This product contains toluene. Toluene has been reported to decrease <br /> immunological responses in Lest animals. It has also been reported that <br /> when young rats were exposed to 1000 ppm toluene for 14 hour:,. Gaily, for <br /> two weeks, irreversible hearing loss was detected. The same (1a:ly exposure <br /> to 700 ppm for as long as 16 weeks was without effect. Since the level <br /> loss is greater than 7 times ms <br /> ht- 98 7-88 <br /> necessary to produce hearing t or below 100 pp <br /> ACGIH TLV for toluene, worker exposures a <br /> effect. There are also report:: that chronic <br /> expected to cause any adverse <br /> abusers (glue sniffers, solvent huffers) of solvents contair,.nc toluene <br /> have suffered liver, kidney and brain damage. Scientific st•idses on <br /> led to demonstrate birth defects in rats and mice. <br /> bs in <br /> However, toluene has been shown to cause delayed growth and extra ri <br /> toluene have fai <br /> the offspring of rats and mice at inhaled doses (266-399 beenpsho�nthat <br /> towere <br /> cause <br /> non-toxic �o the mother. Toluene has not conclusively <br /> adverse reproductive effects in humans. <br /> 'Phis product contains xylene, a chemical that has been reporte& to cause <br /> 3evelopmental toxicity in rats and mice exposed by inhalation curing <br /> ;)regnancy. The effects noted consisted of delayed devY�oemeetcsed byno <br /> skeletal variations; additionally, when pregnant mice P ' <br /> ingestion to a level that killed nearly one-third of the test group, <br /> cleft e) <br /> aethality (resorptions) and malformations (primarily haiation <br /> occurred. Malformations have not been reported following inha)a <br /> is of exposure used <br /> exposure. Because of the very high levein these <br /> risk of <br /> these <br /> studies, we do not believe that their results imply an increas <br /> reto workers exposed to xylene le <br /> productive toxicity vels at or below the <br /> exposur(. standard. <br /> ng <br /> Xylene 'r.as given negative results in <br /> sponsoredl mutagen ebyitheat•ational <br /> including the Ames assay. gave no evidence of <br /> Toxicol()gp Program WTP) , technical grade xylene <br /> carcinotsenicity in rats or 'Rice dosed daily for two years. <br /> Whole gasoline exhaust was reviewed by the International Agency for <br /> Researc`. ❑n Cancer (IARC)-in-their--Monograph_Volume 46-d inadequate in animals and-in(1989). Bvi ence <br /> for cau:.inn cancer was considered equa e — <br /> KSDS Nualber: 000372 <br /> - 90 <br /> Revision Number: 12 Revision Date: NA�x;Hot Not <br /> NDA.- No Data Available <br />