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11 <br /> Mam <br /> CHEVRON Supreme Unleaded Gasoline Page a of SO <br /> 04-CA Prop. 65 05-MI 406 06-IARC Group 1 <br /> 07-IARC Group 2A 08-IARC Group 2B 09-SARA 302/304 <br /> 10-PA RTK ll-NJ RTK 12-CERCLA 302.4 <br /> 13-MN RTK 14-ACGIH TLV 15-ACGIH STEL <br /> 16-ACGIH Calculated TLV 17-OSHA PEL 18-OSHA STEL <br /> 19-Chevron TLV 20-EPA Carcinogen 21-TSCA SECT 4 <br /> 22-TSCA SECT.5 SNUR 23-TSCA SECT 6 RULE 24-TSCA SECT 12 EXPORT <br /> 25-TSCA SECT 8A CAIR 26-TSCA SECT 8D REPORT 27-TSCA SECT GE <br /> "3-Canadian WHMIS <br /> 11. PRODUCT TOXICOLOGY DATA <br /> EYE IRRITATION: <br /> The Draize Eye Irritation Score {range, 0-110) in rabbits is 0. <br /> SKIN IRRITATION: <br /> 1'he Draize Skin Primary Irritation Score (range, 0-8) for a 4-hour <br /> exposure (rabbits) is 0.98. This material was not a Skin sens;tizer in <br /> the modified Buehler Guinea Pig Sensitization Test. <br /> DERMAL TOXICITY: <br /> The dermal LD50 in rabbits is > 5 ml/kg. <br /> RESPIRATORY/INHALATION: <br /> NDA. <br /> INGESTION: <br /> _., The oral LD50 in rats is > 5 ml/kg. <br /> ADDITIONAL TOY.ICOLOG. DATA: <br /> Lifetime inhalation of whole gasoline vapor has caused increased liver <br /> tumors in female mice. The mechanism of this response is still being <br /> investigated but it is thought to be an epigenetic process unique to the <br /> female mouse. Inhalation exposure to whole gasoline vapor also caused <br /> kidney damage and eventually kidney cancer in male rats. <br /> No other animal model studied has shown these adverse kidney effects and <br /> 1" there is no physiological reason to believe that they would occur in man. <br /> The cause of the kidney tonicity is thought to be due to the interaction <br /> of isoparaffin hydrocarbons in the product with a specific serum protein, <br /> alpha-2-microglobulin. Male rats synthesis large amounts of this protein <br /> which is filtered, reabsorbed, and degraded by their kidneys. <br /> ]soparaffins or their metabolites combine with this protein and make it <br /> _ "undigestable" by the kidney proteases. With repeated exposure, the <br /> protean-isoparaffin complex accumulates in the kidney tubules causing <br /> significant cell death and regrowth. It is thought that this continuous <br /> kidney injury may contribute to the eventual development of the tumors. <br /> The data above is+obtained from studies sponsored by the American <br /> Petroleum lnstitute (API). <br /> 12. ADDITIONAL HEALTH DATA <br /> ADDITIONAL HEALTH DATA coKKENT: <br /> This product contains benzene. The OSHA Benzene Standard (29 CFR <br /> Revision Number: 13 Revision Date: 03/24%90 hL5D5 Hubert 001376 <br /> NDA - No Data Available NA - Not Applicable <br />