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` Page 9 of 10 <br /> (ELKVRON Supreme Ualcaded Gasoli.t+e <br /> 1910.102B) contains detailed recuirements for training, expo::ure <br /> monitoring, respiratory protection and medical surveil.lance triggered by <br /> the exposure level. Refer to the osHA Standard before using this product. <br /> Repeated or prolonged breathing of benzene vapors has been a:"sociated with <br /> the development of chromosomal damage in experimental animals and various <br /> blood diseases in humans ranging from aplastic anemia to leukemia (a form <br /> of cancer). All of these diseases can be fatal. No birth defects have <br /> been shown to occur in pregnant laboratory animals exposed to doses not <br /> toxic to the mother. However, some evidence of fetal toxicity such as <br /> delayed physical development has been seen at such levels. Tie available <br /> information on the effects of benzene on human pregnancigs ia• inadequate <br /> but it has been established that benzene can cross the human placenta. <br /> This product contains• n-hexane. Prolonged or repeated skin conot= ive <br /> ct or <br /> breathing of vapors may cause nerve damage characterized by progressive <br /> weakness and numbness in the arms and legs. Recovery ranges from no <br /> recovery to complete recovery depending upon the severity of the nerve <br /> damage. <br /> This product con�ains toluene. Toluene has been reported tc cecrease <br /> immunological responses in test animals. It has also been reported that <br /> when young rats were exposed to luno ppm toluene for 14 hours daily, for <br /> two weeks, irreversib]e hearing lass was detected. The same Gaily exposure <br /> to 700 ppm for as long as 16 weeks was without effect. since the level <br /> necessary to produce hearing loss is greater than 7 timEs ms <br /> h� l957 <br /> not-BB <br /> ACGIH TLV for toluene, worker exposures he or belowre are also <br /> reports that chronic <br /> PP <br /> expectad to cause any adverse effect. Ther <br /> abuser: (glue sniffers, solvent huffers) of solvents <br /> ontascientific studgetoluene <br /> es on <br /> have suffered liver, kidney and brain damage. <br /> ` nstrate birth defects in rats and. mice. <br /> toluen+e have failed to demoe delayed growth and <br /> However, toluene has been shown to caus 'xthatrwerein <br /> the of .spring of rats 'ard mice at inhaled doses (266-399 pp <br /> M non-to::ic to the mother. Toluene has not conclusively been shown to cause <br /> adverse reproductive effects in humans. <br /> This product contains xylene, a chemical that has been reported to cause <br /> developmental toxicity in rats and mice exposed by inhalation during <br /> pregnancy. The effects noted consisted of delayed development and minor <br /> -tal variations; additionally, when pregnant mice were exposed by <br /> sitel <br /> T killed nearly one-third <br /> cepalate)p <br /> ingestion to a level that left <br /> -- lethality (resorptions) and malformations (primarily <br /> occurred. Malformations have not been reported following inhalation <br /> ese <br /> exposure. Because of the very high levels of exposurincreasedused in riskof <br /> studies, we do not believe that their results imply ail e <br /> reproductive toxicity to workers exposed to xylene levels at or below the <br /> exposure standard. <br /> Kvlene has given negative results in several mutagen testing assays <br /> including the Ames assay. Ip a cancer study sponsored by <br /> the tional <br /> Toxicology Program (NNP), technical grade xylene gave no evidence of <br /> ice dosed daily for two years. <br /> carcinogenicity in rats or m <br /> Whole gasoline exhaust was reviewer by the International Agency for <br /> + Research on Cancer (IARC) in their Monograph Volume. 46 (1989). Evidence <br /> KSD.5 Number: o01376 <br /> - Revision Number: 13 Revision Date: 03/24/ t Applicable <br /> NDA - No Data Available NA - Not <br /> i <br />