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ARCADES 1381 Mr. Brian Taylor <br /> July 27,2007 <br /> Risk Characterization <br /> Using standard equations recommended by Cal-EPA and USEPA,the predicted <br /> indoor air concentrations, and the exposure assumptions and toxicity criteria <br /> described above,the potential health risks and hazards were estimated for onsite <br /> office workers. The potential health risks presented by carcinogenic chemicals, such <br /> as benzene, are described in terms of excess cancer risk, or the probability of getting <br /> cancer over a lifetime that may be associated with the particular exposures <br /> evaluated. Noncarcinogenic chemicals,such as toluene, ethylbenzene, and xylenes <br /> are expressed in terms of a hazard quotient or a ratio of the chemical exposure <br /> estimate to a"safe"dose.Assuming the risk and hazard estimates are additive, <br /> chemical-specific risk and hazard estimates were then summed to estimate the total <br /> (cumulative)carcinogenic risk and hazard index(HI). <br /> Based on indoor air concentrations predicted by the GW-SCREEN model shown in <br /> Attachment A,Table 5 presents the estimated excess lifetime cancer risk and <br /> noncancer hazard index for onsite office workers assuming maximum COPC <br /> concentrations in groundwater beneath the building. Tables A-1 to A-10 in <br /> Attachment A present the GW-SCREEN model runs for each COPC assuming slab- <br /> on-grade building foundation and maximum COPC groundwater concentrations as <br /> the source beneath the office.As shown in Table 5,the potential excess lifetime <br /> cancer risk was estimated to be 1 x 105 for an onsite adult office worker. The <br /> potential noncancer hazard index(for total exposure to BTEX,and MTBE)was <br /> estimated to be 0.05. <br /> Table 6 shows a comparison of COPC groundwater concentrations with Cal-EPA <br /> San Francisco Bay Regional Water Quality Control Board (SFB-RWQCB,2005) <br /> ESLs. Maximum and arithmetic average COPC concentrations detected in MW- <br /> 69UA and WSWA were compared with groundwater ESLs for the evaluation of <br /> potential vapor intrusion concerns based on either high or low/moderate vadose- <br /> zone permeability. None of the maximum COPC concentrations in groundwater <br /> exceeded the ESLs. <br /> Uncertainties <br /> Uncertainty,which includes natural variability and incertitude originating from a lack <br /> of understanding (i.e., relevant data)are inherent in the risk assessment process. <br /> Many of the variables used to estimate risks and hazards are standard default values <br /> and may not accurately describe future conditions or characteristics of the site.As <br /> default values tend to overestimate exposure,the impact of this uncertainty is to <br /> typically overestimate risks. <br /> Page: <br /> G,M 11D AIWINI W17111W i 1MM EnWM.tlea 4/7 <br />