SITE INFORMATION AND CORRESPONDENCE_FILE 1

Home Browse Search

UNLEADED GASOLINE(UNBRANDED) MSDS No.APPC975 Ver. 1 11. TOXICOLOGICAL INFORMATION Toxicological The information found in this section is written for medical, toxicology, occupational health Information and safety professionals. This section provides technical information on the toxicity testing of this or similar materials or its components. If clarification of the technical content is needed, consult a professional in the areas of expertise listed above. Inhalation Toxicity studies on this material resulted in LC50 values greater than 5.0 mg/I indicating a low potency. There were signs of respiratory tract irritation and central nervous system depression. Eye Contact Minimal to no irritation in animal studies. Skin Contact Animal studies resulted in moderate skin irritation following short term or prolonged/repeated exposure. The acute dermal toxicity tests indicate LD50 values greater than 2.0 g/kg indicating a low potency. Exposure to sunlight does not increase skin irritation. This material appears to be non-sensitizing. Ingestion The acute oral toxicity tests produced LD50 values greater than 5.0 g/kg indicating a low potency. There were signs of gastrointestinal tract irritation and central nervous system depression. Prolonged/ Twenty-eight day dermal toxicity studies resulted in moderate skin irritation. In some studies Repeated changes in liver, kidney, testes and whole body weights were noted, but no significant Exposures systemic tissue changes characteristic of disease. Ninety-day dermal toxicity studies with similar material resulted in moderate skin irritation and not other significant observations or systemic tissue changes characteristic of disease. Twenty-eight day inhalation toxicity study similar materials resulted in kidney damage in male rats. A two-year inhalation study with a generic unleaded gasoline formulated by the American Petroleum Institute caused kidney damage and kidney tumors in male rats and liver tumors in female mice. These effects are considered specific to these laboratory animals and not applicable to humans. Exposure to components of gasoline such as benzene, toluene, xylene, ethylbenzene, trimethylbenzene, and N-hexane has also been shown to affect reproductive capacity and/or fetal development in laboratory animals. Studies with laboratory animals(dogs) indicate that exposure to extremely high concentrations of gasoline (greater than 50,000 ppm) may cause irregular heartbeats and sudden death. Exposures of laboratory animals to some components of this material at very high concentrations, well above the recommended exposure limits in Section 2, have resulted in cardiac sensitization with irregular heartbeats. Exposure to n-hexane at concentrations considerably higher than the current permissible exposure limit has reportedly been associated with peripheral neuropathy. Commercial hexane exposures up to 9000 ppm were not carcinogenic in laboratory animals. In animal studies and in workers with chronic benzene poisoning, alterations in structure of chromosomes in bone marrow and white blood cells have been observed. Additional Exposures to ethanol in gasoline are considerably lower than levels which have caused Ethanol Toxicity adverse health effects. Adverse health effects are not expected to occur at exposure levels Information typically encountered in the use of ethanol as a gasoline additive. Prolonged and repeated exposure to ethanol vapor above 1000 ppm may cause headache, lack of coordination, sleepiness, fatigue, and difficulty concentrating. Chronic ingestion of ethanol in the form of alcoholic beverages has resulted in liver, stomach, heart and nervous system damage as well as cancers of the mouth, pharynx, larynx, esophagus, and liver in humans. Repeated ingestion of ethanol in the form of alcoholic beverages by pregnant women has caused miscarriage, premature birth and low birth weight, and birth defects (fetal alcohol syndrome). Additional MTBE at very high exposure levels (8000 ppm)did induce developmental toxicity in mice, MTBE Toxicity but only at levels where there was also maternal toxicity. In rabbits exposed to the same Information MTBE levels, there were no indicators of any effects on the offspring, even in the presence of maternal toxicity. The abnormal findings in the mice (cleft palate, etc.) are well- recognized effects of stress in the pregnant mouse and have no correlation with development hazards in humans. Print Date:05/19/2003 Page 6 of 8