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SAFETY DATA SHEET RD03- <br /> ISSUED: 8/3/2018 <br /> 1004 CARDINAL <br /> REFERENCE: D03-TO09 <br /> Germ cell mutagenicity In vivo tests showed mutagenic effects <br /> Germ cell mutagenicity -AMES test- Positive <br /> mouse- male <br /> Germ cell mutagenicity -AMES test- S. Positive <br /> typhimurium <br /> IARC No component of this product present at levels greater than or equal to <br /> 0.1%is identified as a probable, possible or confirmed human carcinogen <br /> b IARC <br /> NTP No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a known or anticipated carcinogen by NTP <br /> OSHA No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by OSHA <br /> Reproductive toxicity No data available <br /> Respiratory or skin sensation - May cause sensitization by skin contact <br /> Maximization test - guinea pig <br /> Skin irritation - rabbit Mild skin irritation - 24 hours <br /> Specific target organ toxicity - repeated No data available <br /> exposure <br /> Specific target organ toxicity- single No data available <br /> exposure <br /> Aluminum Oxide 1344-28-1 <br /> Acute oral toxicity - LD50 - rat > 5000 mg/kg <br /> Acute toxicity - dermal No data available <br /> Acute toxicity - LC50 - inhalation - rat > 2.6 m L 4 h <br /> Acute toxicity - LD50 - oral - rat > 10,000 mg/kg <br /> Additional information Cough, chest pain, difficulty in breathing, gastrointestinal disturbance <br /> Addittional information Liver irregularities based on human evidence <br /> Aspiration hazard No data available <br /> Carcinogenicity This product is or contains a component that is not classifiable as to its <br /> carcino enicty based on its IARC ACGIH NTP or EPA classification <br /> Eye irritation - rabbit No eye irritation <br /> Eye irritation - rabbit Not irritating <br /> Genotoxicity - in vitro -Ames test- Negative <br /> Salmonella typhimurium <br /> Germ cell mutagenicity No data available <br /> Human experience If the recommended workplace concentration of the product is exceeded <br /> the respiratory tract may be mechanically overcharged as with other fine <br /> dusts. <br /> IARC No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a probable, possible or confirmed human carcinogen <br /> b IARC <br /> NTP No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a known or anticipated carcinogen by NTP <br /> OSHA No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by OSHA <br /> Repeated dose toxicity - inhalation - rat Sediment in the lungs/ no evidence of fibrosis, no pathological changes/ <br /> and hamster 2 years <br /> Reproductive toxicity No data available <br /> Respiratory or skin sensitisation - DId not cause sensitisation on laboratory animals <br /> maximisation test-guinea pig <br /> Sensitization - Draize-test- guinea pig Not sensitizing <br /> Skin irritation - rabbit No skin irritation <br /> j Skin irritation - rabbit Not irritating <br /> Specific target organ toxicity - repeated No data available <br /> exposure <br /> Specific target organ toxicity - single No data available <br /> exposure <br /> Amorphous Silica 112926-00-8 " <br /> ACGIH no component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by ACGIH <br /> Acute toxicity no data available <br /> Acute toxicity: Dermal no data available <br /> Acute toxicity: Inhalation no data available <br /> I <br /> Page 4 of 10 <br />