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CARDINAL SAFETY DATA SHEET R <br /> ISSUED: � <br /> REFERENCE: D03-TO3-T009 <br /> Additional information Amorphous silica is not classified as to its carcinogenicity to humans, <br /> however, crystalline silica inhaled in the form of quartz or cristobalite from <br /> occupational sources is carcinogenic to humans (Group 1, IARC). <br /> Therefore, amorphous silica should be handled as if possessing the same <br /> hazards as the crystalline form. To the best of our knowledge, the <br /> chemical, physical, and toxicological properties have not been thoroughly <br /> investi ated. <br /> Additional information Stomach - irregularities - based on human evidence <br /> Aspiration hazard no data available <br /> Carcinogenicity: IARC: Group 3: not classifiable as to its carcinogenicity to humans <br /> Eye irritation no data available <br /> Germ cell mutagenicity no data available <br /> NTP no component of this product present at levels greater than or equal to <br /> 0.1% is identified as a known or anticipated carcinogen by NTP <br /> OSHA no component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by OSHA <br /> Reproductive toxicity no data available <br /> Respiratory or skin sensation no data available <br /> Skin irritation no data available <br /> Specific target organ toxicity - repeated no data available <br /> exposure <br /> Specific target organ toxicity - single no data available <br /> exposure <br /> Barium Sulfate 7727-43-7 <br /> ACGIH No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by ACGIH <br /> Acute toxicity- Dermal No data available <br /> Acute toxicity- inhalation No data available <br /> Additional information Prolonged inhalation of dust may cause baritosis, a benign <br /> pneumoconiosis. If ingested, the presence of soluble barium salts as <br /> impurities may cause toxic reactions due to bioaccumulation., Damage to <br /> the lungs.,To the best of our knowledge, the chemical, physical, and <br /> toxicological properties have not been thoroughly investigated. <br /> Additional information Stomach irregularities - based on human evidence <br /> Aspiration hazard No data available <br /> Carcinogenicity - rat - intrapleural - Equivocal tumorigenic agent by RTECS criteria. Lungs,Thorax, or <br /> tumorigenic Respiration: Tumors <br /> Eye irritation No data available <br /> Germ cell mutagenicity - mouse - No reported data <br /> micronucleus test <br /> IARC No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a probable, possible, or confirmed human carcinogen <br /> b IARC <br /> NTP No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a known or anticipated carcinogen by NTP <br /> OSHA No component of this product present at levels greater than or equal to <br /> 0.1% is identified as a carcinogen or potential carcinogen by OSHA <br /> Reproductive toxicity No data available <br /> Respiratory or skin sensation No data available <br /> Skin irritation No data available <br /> Specific target organ toxicity - repeated No data available <br /> exposure <br /> Specific target organ toxicity - single No data available <br /> exposure <br /> Titanium Dioxide(13463-67-7) <br /> Acute toxicity - inhalation No data available <br /> Acute toxicity - LD50 - dermal - rabbit > 10000 mg/kg <br /> Acute toxicity - LD50 -oral - rat > 10000 mg/kg <br /> Additional information To the best of our knowledge, the chemical, physical, and toxicological <br /> properties have not been thoroughly investigated <br /> Aspiration hazard No data available <br /> Eye irritation - rabbit No e e irritation <br /> Germ cell mutagenicity - hamster- lungs DNA inhibition <br /> Germ cell mutagenicity - hamster- ovary - No results available <br /> micronucleus test <br /> Germ cell mutagenicity - hamster- ovary - No results available <br /> sister chromatid exchange <br /> Page 5 of 10 <br />