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c. When autoclaving mixed waste, precautions must be taken to avoid the release of volatile radionuclides and toxic chemicals. The potential volatility of the mixture when subjected to the elevated temperatures necessary to achieve thermal biological inactivation therefore an important factor in the assessment of these types of mixed wastes. d. Trace chemotherapy and other hazardous drugs should be disposed of by a regulated medical waste company through incineration [ASHP 1995; OSHA 1999; Smith 20021. These recommendations are consistent with current knowledge of the toxicity of antineoplastic (cytotoxic, chemotherapeutics, anti- cancer agents, etc.) and other hazardous drugs, that suggest bulk hazardous drugs (i.e. greater than 3% of the initial volume) not listed under RCRA be handled similarly to hazardous waste and disposed of in a RCRA-permitted hazardous waste incinerator. Hawaii Medical Vitification suggest that no greater than 10% of the waste can be disposed of via plasma arc vitirfication. 1. No biohazardous waste or potentially infectious materials must be allowed to enter a building's drainage, vacuum, or refuse disposal system without proper sterilization. 2. Terminal disposition of biological agents and all materials contaminated or suspected of being contaminated, including dead animals, tissues, plants, plant parts, equipment, etc. must be preceded by inactivation by an approved method for the agents involved prior to disposing or cleaning. C. •Labels, 1. A universal biological hazard symbol (UBHS) is used to indicate the actual or potential presence of a biohazard and to identify equipment, containers, rooms, materials, experimental animals, or combination that contain, or are -contaminated with, viable biological commodities. 2. Proper identification of biohazardous agents is necessary to alert support personnel who may enter the area, to take precaution and to restrict traffic to hazardous areas. It is the primary responsibility of the principal investigator to identify properly all biohazards. 3. The UBHS must be placed so that it can be easily seen and displayed only for the purposes of signifying the presence of actual or potential biological hazards. 4. The UBHS is a fluorescent orange or an orange -red color. There is no requirement for the background color as long as there is sufficient contrast to permit the symbol to be clearly defined. The symbol must be as prominent as practical, of a size consistent with the size of the equipment or material to which it is affixed, and easily seen from as many directions as possible. 5. Appropriate wording may be used in association with the symbol to indicate the nature or identity of the hazard, name of the individual responsible for its control, precautionary information, etc., but never should this information be superimposed on the symbol. fileWCADocuments and Settings\OwnerWy Documents\P&PUnfection Control 2005\Bioha... 5/5/2005