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DEPARTMENT OF HEALTH SERVICES <br /> TOXIC SUBSTANCES CONTROL PROGRAM <br /> TOXICOLOGY AND RISK ASSESSMENT UNIT <br /> SCIENTIFIC GUIDANCE MEMO 89-2 <br /> August 4, 1989 <br /> Page 4 of 4 <br /> Use of Non-Detect and Limit of Detection Values <br /> in Exposure Assessments <br /> Example <br /> Sample 1 Sample 2 Sample 3 <br /> Conc. LOD Conc. LOD Conc. LOD <br /> xylene ND 10 ND 200 ND 200 <br /> toluene 2 , 000 10 20, 000 10 10, 000 10 <br /> Data have been statistically analyzed by the author of the report <br /> and shown with a high degree of certainty to be lognormally <br /> d1s..L _✓.... <br /> Cribb ,*ed. To estimate xylene concentration in <br /> Sample 1 LOD/1. 414 = 10/1. 414 <br /> Sample 2 LOD/1. 414 = 200/1. 414 <br /> Sample 3 LOD/1. 414 = 200/1. 414 <br /> For Wore detailed information on these points, see <br /> EPA (1988) . Proposed Guidelines for Exposure-Related <br /> Measurements. Office of Health and Environmental Assessment, <br /> Washington D. C. Draft Report. <br /> R. Hornung and L. Reed (1987) . Estimation of average <br /> concentration in the presence of a non-detectable value. NIOSH, <br /> Dept. of Public Health, Cincinnati, Ohio. Draft report. <br /> J.A. Frampton (1989) . Soil sampling strategies for hazardous <br /> waste site investigations. California Dept. of Health Services, <br /> Toxic Substances Control Program, Sacramento, CA. Draft report. <br /> This summary was prepared by <br /> Rober_ A. Howd, Ph.D <br /> John P. Christopher, Ph.D. DABT <br /> Richard A. Becker, Ph. D <br /> Toxicology and Risk Assessment Unit <br /> Technical Services <br /> Toxic Substances Control Program <br /> 714/714 P Street <br /> P.O. Box 942732 <br /> Sacramento, CA 94234-7320 <br /> (916) 445-7410 <br />