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Department of .1th S*Mces <br /> !,rate of California <br /> Memorandum <br /> Date August 9 , 1989 <br /> To Section Chiefs <br /> Unit Chiefs <br /> Subbed: Pentachloro- <br /> Staff Toxicologists phenol Poses a <br /> Carcinogenic Risk <br /> to Humans <br /> From Toxic Substances Control Program <br /> 400 P Street, Room 4340 <br /> 324-2425 <br /> Attached please find a preprint of an article scheduled to appear <br /> in the Department of Health Services - Toxic Substances Control <br /> Program (DHS-TSCP) Technical Services Newsletter entitled <br /> "Pentachlorophenol is a CarcTinogen: Derivation of Health-Based <br /> his article for-ns the basis o <br /> Exposure Criteria f Memo <br /> Toxicology and Risk Assessment L'nis for pentachlorophenol <br /> 89-3 . A summary of the derivation off AALs f <br /> is supplied as a part of this memo. <br /> d by the National =oxicology Program (NTP) <br /> Recent studies sponsore <br /> have conclusively shown that pentachlorophenol exhibits <br /> carcinogenic activity in laboratory DHSSCPaevaluatedTtheTdataof�c:� the _ <br /> y and <br /> Risk Assessment Unit of th conthat <br /> NTP studies and found the e e dea hlor phe sol sufficient aso if c itdepcses la <br /> is prudent to consider p <br /> carcinogenic risk to humans. <br /> This finding will undoubtedly i:^.pact ;;pon the assessment of <br /> health risks associated with exposure t� pentachlorophenol from <br /> y in particular awood treatment facilities , in <br /> hazardous wase, t <br /> to DHS-TSCP dealing <br /> the State. Risk assessments to be sub«itted to <br /> uences of expo <br /> with the potential w retch nize constha- pentachlorophenol 'poses <br /> pentachlorchenol must no g Quant- _ <br /> esti-mates c= the <br /> a carcinogenic risk to humans. 4� �� tachlorophenol exposure <br /> cancer risk to humans associated with pen <br /> will now be required. <br /> Applied Action Levels (AALs) for Pentachlorophenol in aim and <br /> water, based upon the carcinogenic potency cf pentachlorophenol, <br /> have recently been established by DHS---SCP. These criteria are <br /> to be used as specified in the California Site Mitigation <br /> the risks associated with <br /> Decision Tree Manual in assessing from hazardous waste <br /> potential exposures from chemicals nanrniag The AALs for <br /> sites and facilities in <br /> pentachlorophenol are: <br /> AAL (air) = 0. 22 ug/m3 <br /> AAL (water) = 2 . 20 ug/L <br />