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James Tjosvold <br /> Page 2 <br /> May 2 , 1989 <br /> 2 . Samples should be collected prior to the last shift of a <br /> work week. Peak urinary concentrations occur <br /> approximately 40 hours following inhalation. The <br /> majority of samples were collected 48 hours after a <br /> weekend. <br /> 3 . The two workers (treaters) with the highest biological <br /> results had the lowest air results for the sampling <br /> population. Graders had the lowest biological and <br /> highest air results, as a population. <br /> Conclusion <br /> Data validation was not possible because analytical and <br /> quality control data was not included for laboratory <br /> analyses. The air results show that workers are over a <br /> ten-fold below the standard set by ACGIH. Animal studies show <br /> that PCP is absorbed better by the lungs than by the skin and <br /> that the metabolic rate is quick. Elevated levels in urine <br /> (500 of limit) after only two working days may suggest further <br /> evaluation is necessary for exposure routes. <br /> Pentachlorophenol has been regulated as a non-carcinogen and, <br /> therefore, most of the standards were set on systemic toxicity <br /> data evaluation. However, in a recent NTP bioassay PCP was <br /> reported to be carcinogenic in B6C3F1 mice. PCP induced <br /> hepatocellular carcinomas and adenomas. <br /> It is, therefore, very likely that the standard set on <br /> non-carcinogenic toxicity will be changed to reflect the <br /> carcinogenic potential . <br /> V <br /> Jeff Van Slooten <br /> Associate Hazardous Materials <br /> Specialist <br />