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SAFETY DATA SHEET Honeywell <br />Solstice® yf Refrigerant (R-1234yf) <br />000000011078 <br />Version 2.3 <br />Revision Date 06/17/2014 Print Date 05/29/2015 <br />: Species: rat <br />Application Route: Inhalation <br />Exposure time: 4 Weeks <br />NOAEL (No observed adverse effect level): <br />: Species: rat <br />Application Route: Inhalation <br />Exposure time: 13 Weeks <br />NOAEL (No observed adverse effect level): <br />: Species: rabbit, male <br />Application Route: Inhalation <br />Exposure time: 28 d <br />No-observed-effect level: 500 ppm <br />: Species: rabbit, female <br />Application Route: Inhalation <br />Exposure time: 28 d <br />No-observed-effect level: 1000 ppm <br />Species: mini-pig <br />Application Route: Inhalation <br />Exposure time: 28 d <br />NOAEL (No observed adverse effect level): <br />Note: highest exposure tested <br />50000 ppm <br />50000 ppm <br />10,000 ppm <br />Genotoxicity in vitro Test Method: Ames test <br />Result: 20% and higher, positive in TA 100 and e. coli WP2 <br />uvrA, negative in TA98, TA100, and TA1535. <br />Test Method: Chromosome aberration test in vitro <br />Cell type: Human lymphocytes <br />Result: negative <br />Note: Dose 760,000 ppm <br />: Test Method: Chromosome aberration test in vitro <br />Cell type: Chinese Hamster Lung Cells <br />Result: negative <br />Genotoxicity in vivo Species: mouse <br />Cell type: Micronucleus <br />Dose: up to 200,000 ppm (4 hour) <br />Result: negative <br />Page 10 / 15