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SAFETY DATA SHEET Honeywell <br />Solstice® yf Refrigerant (R-1234yf) <br />000000011078 <br />Version 2.3 <br />Revision Date 06/17/2014 Print Date 05/29/2015 <br />Genotoxicity in vivo <br />Genotoxicity in vivo <br />Reproductive toxicity <br />: Test Method: Unscheduled DNA synthesis <br />Dose: up to 50,000 ppm (4 weeks) <br />Result: negative <br />Species: rat <br />Cell type: Micronucleus <br />Dose: up to 50,000 ppm (4 weeks) <br />Result: negative <br />: Species: rat <br />Application Route: Inhalation exposure <br />Exposure time: Two-generation reproductive toxicity <br />NOAEL,parent: 50,000 ppm <br />NOAEL,F1: 50,000 ppm <br />NOAEL,F2: 50,000 ppm <br />Teratogenicity : Species: rat <br />Dose: NOAEL (No observed adverse effect level) - 50,000 <br />ppm <br />: Species: rabbit <br />Dose: NOAEL (No observed adverse effect level) - 4,000 ppm <br />SECTION 12. ECOLOGICAL INFORMATION <br />Ecotoxicity effects <br />Toxicity to fish <br />Toxicity to daphnia and other <br />aquatic invertebrates <br />: LC50: > 197 mg/I <br />Exposure time: 96 h <br />Species: Cyprinus carpio (Carp) <br />Method: OECD Test Guideline 203 <br />Note: No demonstrable toxic effect in saturated solution. <br />: EC50: > 83 mg/I <br />Exposure time: 48 h <br />Species: Daphnia magna (Water flea) <br />Method: OECD Test Guideline 202 <br />Page 11 / 15