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_ 001847- No,2 Diesel Fuel Page 819 Date of Issue: MApr-2015 Status: FINAL ------------------------.---------------------------------- M.4P-k-3 2016 Incompatible materials: Avoid contact with strong oxidizing agents and strong reducing agents. ENVIRONMENTAL Hazardous decomposition products: Not anticlpated under normal conditions of use. Information on Toxicological Effects Substance i Mixture � w 2 Inhalation Harmful if inhaled 4.65 mg/L(mist) Dermal Unlikely to be harmful 5,2 g/kg Oral Unlikely to be harmful >5 glkg Aspiration Hazard: May be fafal if swallowed and enters airways. Skin Corrosionllrritation: Causes skin irritation. Repeated exposure may Cause skin dryness or cracking_ Serious Eye Damage/Irritation: Causes mild eye irritation. Skin Sensitization: Not expected to be a skin sensitizer. Respiratory Sensitization: Not expected to be a respiratory sensitizer. Specific Target Organ Toxicity(Single 1=xposure): Not expected to cause organ effects from single exposure. Specific Target Organ Toxicity(Repeated Exposure): May cause damage to organs through prolonged or repeated oxposufe. Repeated dermal application of petroleum gas olls for 90 days resulted in decreased liver,thymus,and spleen weights,and altered bone marrow function. Microscopic-alterations included liver hypertrophy and necrosis,decreased hematopoesis and lymphocyte depletion, Carcinogenicity: Suspected of causing cancer. Petroleum middle distillates have been shown to cause skin tumors in mice following repeated and prolonged skin contact. Follow-up studies have shown that these tumors are produced thrqugh a non-genotoxic macharil associated with frequent cell damage and repair,and that they are not likely to cause tumors in the absence of prolonged skin irritation. Genn Cell Mutagenicity: Not expected to cause heritable genetic effects. Reproductive Toxicity: Not expected to cause reproductive toxicity. Other Comments: Diesel engine exhaust has been classified by the international Agency for Research on Cancer(IARC)and National Toxicology Program(NTP)as a carcinogen. Information on Toxicological Effects of Components Naphthalene Carcinogenicity: Naphthalene has been evaluated in two year inhalation studies In both rats and mice. The US National Toxicology Program(NTP)concluded that there is clear evidence of carcinogenicity in male and female rats based on increased incidences of respiratory epithelial adenomas and olfactory epithelial neuroblastomas of the nose. NTP found same evidence of carcinogenicity in female mice(alveolar adenomas)and no evidence of carcinogenicity In male mice. Naphthalene has been Identified as a carcinogen by IARC and NTP_ f GHS Classification: H411 --Hazardous to the aquatic environment, chronic toxicity --Category 2 Toxic to aquatic life with long lasting effects.