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Wine
<br /> 6CaOCl,.H2O -. 2CHC1g+ (CH,COO),Ca + 2Ca(OH)t + smote aaa aiponm who or stuns fish without render-
<br /> 3CaCl,} 6H,0. May also be prepd by carefully controlled ing thele,inedible. Structure: Marktt. Rohrmadn. ibid.
<br /> 61,
<br /> ct chlorination of methane: Faith. Keyes A Clark's Industrial 947. 3479(1939):Msrktt at at. ibid.62,2537. 3006(1940).
<br /> Chemicals, F. A. Lowenheim, M. K. Moran, Eds.(Wiley- On hydrogenation the 38.68-isomer(B-chloragenin)is pro
<br /> Interscience. New York.4th ed., 1975)pp 266.269. Review duced.
<br /> ' L. R. Pohl, Rev. Biochem. Tosiml. 1,79.108
<br /> oz of toxicology: x
<br /> (1979). Review of carcinogenicity studies: IARC Mono-
<br /> F petr ether or from acetic graphs 20,401-427(1979). "-Cee,
<br /> us 1.6867. bp 31'` Praic Highly refractive. nonflammable, heavy. very volatile. jl3
<br /> a sweet-testing liquid: characteristic odor. di 1.484. by
<br /> Moderately sol un ether, 61-62'. Salidif -63.5`. nN 1.4476. Forms a constant boil- 63
<br /> ilrobenzene. ing mixture with 7%arc,boiling at 57. d 1.474 to 1.478 for
<br /> U.S.P. chloroform cont6 0.5.1%ethanol as stabilizer. One v
<br /> 2-Chloroethanol acetate• ml dissolves in about 200 ml water at 25•. Miac with alto- tees
<br />.20%, H 5.76%. CI 28.94%, - hot, benzene,ether, Petr ether,carbon tetrachloride,carbon
<br /> Prcpn from ethylene oxide disulfide,oils. Pure chloroform is light sensitive and reagent ■ .
<br /> ens. J. Am. Chem. Soc.55, grade chloroform usually contains 0.75%ethanol as stabiliz• No
<br /> er. Protect from light and keep cool LD. orally in rats: a as a
<br /> u 1.4234. Flash pt 53.87 2.18 Blkg,H. F.Smyth et al..Am. Ind. Hyg.Assoc.J.23,95 bee
<br /> 2, 880(1940). Practically (1962).
<br /> Human Toxicity: Inhalation of large doses may cause
<br /> arson, U.S. pat. 7,179,506 hypotension, respiratory anol.sop 277-276'. [a]}[, 52*(chlo-
<br /> nd myocardial depression and Needles from meths
<br /> death. Banned by FDA from use in drug.cosmetic and food roform or isopropanol). Less sol in methanol, more sol in
<br /> packaging products in 1976- This substance has been listed isopropanol than tigogrnin. a
<br /> zylamine Hydrochloride, as a carcinogen by the EPA: Second Annua ,sop 154-155'.
<br /> I Report on Car- Diacetate.crystals from dil methanol
<br /> thy/)benzenemethanamine cinogens(NTP 81-43, Dec. 1981)pp 78-80. Dibmzoa-, crystals from methanol + chloroform, sop
<br /> nzylamine hydrochloride; +9.5'(chloroform).
<br /> e hydrochloride; N•N-di- tta. c a solvent for fats, oils. rubber,alkaloids, waxes. 200.52114 4.5. [a] 1
<br /> hloride; Dibenamine h to lower
<br /> the resins:as cleansing agecarbon
<br /> et fire extinguishers 2114. 1-CC 59.749.. H. n-Hexyl chloride. CyH 3(C moi
<br /> Y' to lower the freezing temp of carbon tetrachloride; in the wt 120.62. C 59.74%. H 10.86%, CI 29.40%. CH,(CHI)4-
<br /> I wt 296.23. C 64.8776•H rubber industry. CH Cf. Prepd from 1-hexanol by treatment with fuming
<br /> ,CH,),NCH,CH,CI.HCI. THERAP CAT: Pharmaceutic aid (solvent). HCI: Henry, Chem. Zentr. 1905,1I,214:with excess SOCI,
<br /> L 826,208 0951 to Bach. THERAP CAT(vED: Has been used as an anesthetic,and as a or with PCI, + ZnCI,: Clark, Streigh6 Trans. Roy. Sac.
<br /> 53). carminative and antispasmodic Can.[3]23,111,77(1929). 'I
<br /> 180-181'(the free base is
<br /> water near neutrality,but 2112. Chlorogenic Acid. 3.11J•(3,4-Dihydmxyphenyf)-I- Mobile liquid. ; n 1.41 . byes 134'. ohs 1.4236(Clark.
<br /> at pH 2.4 and 0.5%at pH oxo•2.pmpenyUaxyl-1,4,5-trihydroxycyclohe..necarborylic Streighb loo dz): n� 1.4195 (Mumford. Phillips. L Chem. I
<br /> Irne glycol. Stable in acid acid; 1,3,d,5.wmhydroaycycloh"an"rbo:y/fe acid 3-(3,4- See 1950, 75). Ineal in water. a to tluhe anolxing �h 10% aq til 1,Iii
<br /> neutral or alkaline wins. dihydroxycinnamate); 3•cafteoylquinic acid: 3-(3.4-0ihydr- NaOH decompous j
<br /> Nickerson, Nomaguchi. J. oxycinnamoyl)quinic acid. C„H„Or mol wt 354.30. C 2115. a•Chlorehydrin. -1,2-propanediol; 3-
<br /> 1951). 54.24%. H 5.12%,O 40.64%. important factor in plant me- chloro-l.2-dihydroxypropane: a-monochlorohydrin; B•B'-
<br /> er; diagnostic aid (pheo- labolism. facto from green coffee beans: Freudenberg. Bar. dihydroxyiwpropyl chloride: glycerol a-monochlorohydrin;
<br /> 53,237(1920). Chlorogenic add and its isomers isochloro- 3-chlot propylene glycol: EPibloc. C,H,CIO; mol wt
<br /> (line. 7•(2-Chlotoeth [)- genic acid and neechlorogenic acid occur also in fruit.leaves 110.54. C 32.59%.H 6.38%.CI 72.08%.O 28.95°. CH,CI-
<br /> Y Y and other tissues of dicotyledonous plants: Sondheimer. CHOHCH,OH. Prcpd from glycerol and HCI gas: Conant.
<br /> We-Z&f ione; Eupnophile. Arch. Pharm.293,721 (1960). Forms ca(fcic acid on hydro-
<br /> 44.55%. H 4.57%, CI lysis: Fiedler. 3,72 (1960). Fo. s ca (1954). Structure: QwYle. Org- Syn.call.vol.1,294(194 U. I,
<br /> re n: Cacace et al., Ann Liquid. Sweetish taste. Tendency to turn straw color. df
<br /> P Fischer. Dan6schal. Bar. 65, 1037 (1932): Baines ¢t al. J. 1.3218. n�j 1.4831. bple 213' (dee); bpi, 114-120% bpi,
<br /> 71 (1956). Am. Chem. Soc 72,4178 (1950); Corse et al.. Tetrahedron 115-IIT. Sol in water,alwhat,ether. LDJe orally in mice.
<br /> 18, 1207(1962). Synthesis: Panizri et at.. GO ZL Chim. ItaL rats: 0.16,0.15 g/kg,C.H.Hine et al..Arch. Ind. Health 14,
<br /> CH C1 86,913(1956). 250(1956)
<br /> 2 2 . �.,
<br /> OSE: To lower the framing point of dynamite;in the manuf
<br /> at of dye intermediates. As rodent chemosterilant.
<br /> 2116. Chloromethyl Methyl Ether. Chloromehoxymeth-
<br /> a R aaCCTl=at f-� an ane;methyl chloromethyl ether; monochioromethyl ether; Ij
<br /> chloncx imethyt ether;CMME. C,H,CIO; mol wt 80.51. C
<br /> xaoc x 29.84%, H 6.26%, CI 44.03%. O 19.87%. CH,OCH,CI.
<br /> x H Prepd by passing HCI through a mixture of formalin and
<br /> x a methanol: C.S.Marvel. P. K. Porter. Org.Syn.call.vol. I, I
<br /> r,mp 121.5-122.5'. Spar- xo an 377(1941). See also Beilstein 1,560(1918)and supplements. �.
<br /> mamide to increase soly: Commercial product usually contaminated by sym-dichloro-
<br /> to Endo Labs.). x as methyl ether, q x Review and evaluation of studies of Car-
<br /> cinogenicity in laboratory animals: IARC Monographs d,
<br /> er. (2•Chlonrethoxy)eth- Hemihydrate, needles from water. Becomes anhydr al 239-245(1974). 05.
<br /> C 45.08%, H 6.62%. Cf 110•. sop 208'. [ale -35.2'(c = 2.8). K at 27' = 2.2 X Colorless liquid,by 57. dm L06rap 1.39737.
<br /> H-CH,. Maybe prepal 10-1 R/values: Fiedler. lac cit. Soly in water at 25 about Note: The technical grade has been listed as a carcinogen
<br /> riethanolamine upon B.B'- 4%,much more sol in hot water. Alkaline wins acquire an by the EPA: Second Annual Report an Carcinogens(NTP
<br /> Perkins, U.S. pat. 2,104,- orange color. Freely sol in alcohol, acetone. Very slightly 81-43 Dec 1981)pp 63-67.
<br /> Chem.); cf.Cretcher et al., sol in ethyl acetate. Healing with dil HCI yields caffeic acid. USE:, In synthesis of chloromelhylated compounds.
<br /> I Forms a black compd with it,,, said to be responsible for
<br /> e.
<br /> Quite stable to NaOH the blackening of cut and cooked potatoes: Chem. h Ind. BB2dimcthYCh^YI chloride; socrotlyl chlorides C,H,CI Ime[
<br /> ydrolysis to acetaldehyde (London)1958,627.
<br /> rcelhanol]. LD,r orally in 3'-Methyl ether, CnH2Or 3•Jeruloy/quinic arid. Crys- wt 90.55. C 53.05%. H 7.79°/.Cl 39.16%. Preen from iso-
<br /> Ind. Hyg. Tox.o 3l,60 tats from ethyl acetate + petr ether, mp 196-197°. [a] butyraldebyde: Kirrmann. Bull. Son. Chim. France 1948,
<br /> -42.8° (ethanol). uv max (ethanol): 725 nm if 19.200 163-1 by 801/ H,SO4 meri�tinm If Baekhurst el .1, J.oChemet Soc.r1959. 2742.
<br /> cellulose ethers. 2113. Chlorogenin. (25R)-5a-Spirostan-3B.6a-diol.
<br /> ethane. CHCI,; mol wt C27Ha,0a; mol wt 432.62.' C 74.96%. H 10.25%,O 14.79%.
<br /> ethane.
<br /> Improperly called isoln from bulbs of the California soap plant.amole: Chia- CIH3
<br /> acetone and bleaching k raga/um pomendianum(DC.)Kur Libloroe: in Occng.urs
<br /> rs in Ca c=CHCI
<br /> acid: 2CH,COCH, + ter,J.Am Chem.See.57,525(1935). Chlorogenin octan in S
<br /> Page 301
<br /> Consult the cross indexbefore using this section.
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