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''v°..a; r�, .,�V; •e,'v ,. ,. #.' n;r rx xaa. *': ' <br /> 5 <br /> FUZL OILS <br /> 66-19 <br /> o= :he animals c°vcloQed a vocal or- 12 rumors. Each tumor-bearing <br /> w mouse had an average of 2.4 tumors, the hydrotreated FOB was also <br /> casted for promoting activity, In these studies, mice were initiated <br /> reeks with 50 ;LL of-ith 50 ug DMSA. After 2 weeks- rhev were ce weekly for 2S <br /> 1;3 soluzic.r promoted ::riof hy <br /> was treated with aracreaced FOB in ace[ore. The <br /> control group acetone for 2 weeks and similarly <br /> promoted with the hydrotreated FOB. The hydrocreaced FOB possessed <br /> measurable rumor promoting activity. when DHBA was used as the <br /> initiator. 419 0£ the mice had rumors after 6 months. Each mouse had <br /> an average of B tumors, No tumors were reported in mice created with <br /> hydrotreated FOB on noninitiaced (acetone-created) skin. <br /> 66.3.1-2 Hutagenicitv <br /> API has conducted a battery of 3 tests to evaLuace the <br /> mucagenicity of diesel fuel and number 2 fuel oil (1914). <br /> Number 2 fuel OLI (50% cacalv <br /> rather than negative tically cracked stock) gave positi•;e <br /> results in each test, :n the Ames assay, it was judged to be e°uivoc4L <br /> because the relatively high mucanz Lrtquencies <br /> S u 'um strain T.08 were observed in <br /> mouse lymphoma assay, at 4 concentrations. In a <br /> non-activation conditions, ` <br /> it <br /> as test concentrate undermucaganic of 12Civacion and <br /> mutaci°n frequency was ,7 times the so?veno control without00 PS/mL. the <br /> necabolie <br /> 4 activation. In a rat bone marrow cytogenetic study, Sprague-Dawley <br /> vacs were administered number 2 fuel oil dissolved in corn oil by <br /> gavage at dosages ranging from 0.125 to 1.25 g/kg/dav for 5 days. The <br /> percentage of aberrant cells ranged from 7.5 to 12.58, A high <br /> percentage of cells with chromatid breaks tea:, seen at all .reatment <br /> levels. In both cases, the increases were �'catiscically significant <br /> only at the Lo'w and high dose Levels. <br /> Diesel fuel gave negative results in both the kmes and mouse <br /> Iymphoma assay. POSicive results were obtained in the rat bone marrow <br /> cvcogenecic assay. The diesel fuel was administered undiluted by <br /> intraperitoneal injection. Dose was 0.6, 2.0 or 6.0 mL/kg/dav far 1 or <br /> 5 days. Single injections ac the mid- or high-dose, as well as the <br /> high-dose in the 5 day protocol caused statistically significant <br /> increases in chromosome abnormaiities (1914), <br /> 56.3.1.3 Teratogenicity, Embryotoxicity and Reoroducti•re Ef!eccs <br /> One ceracology studv of fuel oil was found. The studv vassponsored by API, rhe material used vas iabelcd "; 'e <br /> specifications - ere provided. From days 6 through 15 sof geacation. <br /> pregnant CRL;COBs CO(SOIER rats were exposed to airborne concentrations <br /> of 0, 86.9 or 408.4 ppm for 6 hours daily. There was no evidence of <br /> teraeogenicicv embrvoeoxicicy or inhibition a£ fetal grouch and <br /> developmant (1915), <br /> 6/87 <br />