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a <br /> } <br /> MCM <br /> 66-20 <br /> Otber Toxicologic cZf£ect; <br /> 66-3.3.4.1 Short-tensa Tax.jci=f <br /> CesrsThe following _sel ails acct=e Loci in b <br /> : <br /> Diesel Fuel (Marketplace sa=ia) <br /> Number 2 fuel oil <br /> Iow-catalytic crack-d (lOg) <br /> m0di-ami-cardlyric crseked (301) <br /> b4h-car,.,17mic cracked (50%) <br /> Number 6 fuel oil <br /> "I gralrLY 11..7/2.74 sulfur content <br /> A'x Sravitg 17.1/0.81 Sulfur consent <br /> API grxviry 23.1/0.21 Sulfur content <br /> AIII gravity 5.2,11.24 Sulfur concent <br /> The 6 tests which were conducted vete: <br /> Primary eye and dextsa3 ix=itatioa in r3;bits <br /> - Acute dere and subacute derral taxici.; is rabbits <br /> Nt Qermxl seasitixat#oa is guinea pigs <br /> Acute oral :axicitp in rats <br /> Results o£ ,-.hes. tests are discussed below. <br /> The acute oral toxicity was .va3uared in Sprague-Davie <br /> "umber 2 ails caused 70 to 1001 mort .0 Y rats, Th. <br /> fig- Ipso values ranged from I2.D to 17-5 with doses of 16.5 to 21 <br /> alopecia, dexsaal Lrritatioa and open sot aroundathe xic s e8r�i sided <br /> The number 6 fuel Oil with ant API specific <br /> _ g area. <br /> sulfur concent waLs the most toxic =aterlsl test d The rf .2 pand 1.21 <br /> ,g/)cg. A dos. or 25 $/kg caused 1001 morrali as 5-1 <br /> number 6 fuel oi.3s csused mortal, 2 t9. None of :hc other <br /> degree of t)' at 2.24 g/kg, A' significant <br /> Sastraithest3stal distYe;,s waw observed at doses greater than <br /> 15-20 g/kg tmtil the ma.eriesl cleared the ga.stroiatestinal stats^. This <br /> Jas thought to be due to volume overload. Yo=ali generally occurred <br /> 2-3 days after dosing. Necropsy xevealed evidence- of heeoccurred <br /> gascroenteritis and pneumonia. with abscess farmar_on (1929). <br /> A marketplace samoie of diesel fuel had an LD of ?.5 g/-iC and <br /> caused 401 marcality at a dose of 16.6 g <br /> as those seen with rhea gig- Toxic sigtz_s were the same <br /> �.. umber 2 oils (1924), <br /> !tale GD-1 mice subjected to nose only expesure of 0.065, 0.135 or <br /> 0.204 mg/l, urcombusted diesel fuel, varsar for 8 hours per day oa 5 <br /> consecutive days devela <br /> amd in some cases, ed vaaodilacioa, ataxia, poor grooming habits, <br /> eaors. 1,11 sign, varied with rhe lase and <br /> - 6/87 <br />