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— x- <br /> FUEL OILS <br /> 66-23 <br /> observed iY to • <br /> brain. skin, `ung' nasai cavity-and sinuses, digestive <br /> been reported pancreas and kidney. Iaukemias and sYster,, <br /> (1817). lys::phOmas have also <br /> n6,3.J 7nxicologY a£ Fuel Oil Comaanents <br /> nents of brief <br /> componOverview of the coxicgiggy of the <br /> =up1 Jar hSdrocarban <br /> Oils are Summarized below se <br /> r�i{ <br /> Hexane may be the mast highly toxic member of the alkanes, <br /> ingested, it <br /> irritationcauses nausea, vertigo <br /> and [YS effects. g bronchial and general incestfnal <br /> hazard- Acute It also prasents an acute <br /> Non-specificeMPosure occurs primarzi•� asPiration <br /> symgtoms such as Curti o, y through inhalation. <br /> are -he first to be manifested. headache. <br /> nausea and vomiting <br /> narcosis-like state 3opear.; as At high concentrations, a <br /> Pre-narcocic svmptoms a result of CNS <br /> 1500-2500 occur at vapor conceorrations ra�epression.:' <br /> PPm. n-hexane irritates the eyes and mucous gls <br /> These effects can be seen after an exposure a 8g0 g f=au <br /> Skin contact membrane.,,. <br /> primarily causes fatremoval and cutaneous irriPPm for tation- <br /> Chronic ex o <br /> P sure to n-hexane r <br /> The first clinical si �pors causes <br /> And fingers. 8n of neural damage is a Pe'-ipheral neuropathy. <br /> Che toes a feelingof numbness <br /> impsfrmenc g is leads to further symmetrical etricsensgry <br /> in the disc:,",; portions of the extremities and to <br /> muscular stretchin <br /> weakness develo s g reflexes. Ultimately,ex loss of <br /> Paralysis develop,,S "riefly in the discal portion <br /> the muscular <br /> walkin P ,it, varying de impaired f the extremieies. <br /> g P , Th)Ls may include musculargrees of acro h grasping and <br /> polyneuro ashy <br /> parallels The development of elecrrophysiola icai(sensorimotor <br /> the severity of Che clinical picture, g changes <br /> cases, nerve conduCtiviCy is neutralized. In the most severe <br /> involvement is also observed. In some cases, cranial nerve <br /> 'within 6 to l4 months After In <br /> ceases, recovery begins <br /> in mild to moderate cases, <br /> Years t serious cases, iZse threshold level at which neuropathy occurs <br /> < � � has not but may take up to } <br /> been timely ecablished but s <br /> People e:,posed to concentrations rangy YmPcoms have <br /> months, been observed in <br /> ming from iJ to 200 ppm for 9-12 <br /> In animals, <br /> vapor signs of narcosis are seen after mice are exposed to <br /> P levels at 16,Gu0 � <br /> concentrations between 4Pm for 5 minutes, peachgenerally <br /> oral LDSG is ciCed `3.800 and 52,000 9-11 occurred at <br /> E as mL/kg for 14.dPv m after 9-1I9 minutes. The <br /> • young adult rats. old rats <br /> and :.9 c�L;4:g for <br /> w Long"turns inhalation experiments in rocs su <br /> signs of neurotor-laity ao ggesc chat che <br /> PPM fcr 24 weaks. Pear after they are exposed to leve Ls first <br /> animals This higher threshold s ,c 200 <br /> may be due to differences ca induce neurecaxicicy is <br /> 2•hexanol is the crier metabolite in auimalsmewhiler�m Specifically, <br /> .5-hexanedione <br /> 6/8; <br /> Ell <br />