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a - <br /> NO <br /> '= A <br /> a 4 <br /> .� = a ops <br /> 66.3-1.4.2 r <br /> CILO�G lO.l'jr; <br /> ?.Ta studies <br /> were fe=d regarding Cho chrome Cox', <br /> or Fsel oils <br /> in animals. <br /> 66.3.2 ri�an and Eoidemiclog-ic Studies <br /> 66.3.2.1 Short-terra Toxicologic :Elects <br /> The chief spsteaic reaction to pet~aleua hpdroca';ber>_s, s.;« as <br /> £txel oiL. is central nervous sysresa depression (17). TFsxicological <br /> effects are et;+ected to xesembEe Chase oz :teraseae; .,g, <br /> moderate darmal and hi a lou oral, <br /> sspitatioa does not occur, �Pation iiarard (I2). Provided ::tat <br /> r• adult cedilla ' :he =Ran oral 'ethal dose oz kerosene for as <br /> red to be 4 to 6 ounces. However, twico this amat�t <br /> � a boon toicrared and less than it hasounce has caused death <br /> eztinara may be lost since oras (17). This <br /> Pigs axcned 20 iso values in rats, rabbits and guinea <br /> -� 24 hours atter�inSe, In fatal poisonings, death may occur wirhi, 2 to <br /> cated ingezrion and tion- The difference betucea cases of uaeemaii_ <br /> gree= a5 a the lethal dose Where aspirariaa occurs May pint and a teaspaon�_ may be as <br /> „'• from asoixarion i, The characteristic lesion resulting <br /> an acute and often fatal bronchopne=onia, �Cerosene <br /> and related hydrocarbonare- also irrita <br /> membrames. Percutaneous adsorptiting to the. skin and mucous <br /> on Any be significant (17). <br /> Aetmn3 exposure to diesel oil has caused aeph;otoxlci_ <br /> who cleaned his <br /> ted•' and arms with diesel oil over several week-- <br /> nausea,experienced sy=ra of epigastric and loin pain. r se <br /> nausea, anorexia, of <br /> swelling. nocturia, <br /> ._; edeas. lienal biopsy revealed ng� severe exhaustion and pitting ankle t <br /> degeneration and necrosis aCttte � necrosis srigry paiy ! <br /> 8 of the <br /> r (1814). Another ease s, proximal and distal tubular epirhelicls <br /> reportaad acute oliguric cs described by 3arrientos et a7 , (1815) who <br /> with diesel oil- allure <br /> in <br /> a par <br /> ionr who had washed his hair <br /> dilation and p renal biopsy Porroraed the next day shoved tubular <br /> y a roziferation of calls in. the glomeruli. Similar <br /> -nephrotoxic effects were reported as a result or <br /> '-� oil vanors in a Cruck cab over a 10 day period (1816).elation a= diesel <br /> {'= 'Licuid pecw'Oleum hydrocarbons carne little or no :ajttry on direct <br /> r� eye contact. Kerosene and netroieum oil rabbit and `ttmar cement <br /> are essentia7.ly on innocuous (1g)_ ce <br /> 66.3. <br /> 2,2 Chronic Toxicologic F4!acts <br /> i� <br /> No studies vete exposure found which evaluated re.e effects or long-term <br /> to fuel oils. However_ • rruserous egidem;ology studies <br /> t evalyati:tg the effects o <br /> ° f pettolewn exuasure have been conduc=ed. <br /> '7leilc most have shown overall standardized mortality -atios to be lower <br /> than those oat the general populati <br /> been observed for cancer, at several sites. <br /> at <br /> nu, elevated numbers of deaths have <br /> are rot Zotmd con:iste However, chese elevat4-ons <br /> ally in all or the s=urlier_ Cancers have been <br /> _ 6/8f <br />