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fd ;',n��� u�i M;:+� Wa;. � '...'t�.�pi aC .:ry. +k s .-. ,�•f!� .yl"&.�f�. 4'�•. ,�•K. ��.e �+'.n p'.w'b yE«�'� R.T� C'�� BA�".,*: <br /> Y� k, �'�*.�-���.a iY.x..� :�'v w ' �i ''�riT�-��'hcr _ 15' -�.. G�!��,�•.. �e��, "c' RY��4"" •� ^3 �"ti'& :7' <br /> S.'3. <br /> .» :ZISL OTL; <br /> 66-25 <br /> '=hich is neurotoxlc, <br /> Of a solvent containzneda�in7[es in man. Chronic topical application <br /> myelin degeneration g 5.21 n-hexane caused axonal swelling <br /> Was I in chicks. ::o clinical signs were seen, and <br /> 8/kg/day for b4 days. ?n rabbits. logical a Dosage <br /> ML/day far up to 7.0 days caused redness, it:topical andls a ifin f0_ <br /> '1-hexane is £ 0.5 <br /> neither carcinogenic or [eratagenic. One v vo study in <br /> rats that inhaled 150 ppm Eor 5 days found an increased chromosome aberrations in the bone marrow cells. <br /> mutagenxcic•r, nui�bar of <br /> reproductive toxicity or carcinogenicity No <br /> aastudies <br /> suere <br /> - found (12,1930,1935), <br /> Q a <br /> $Y the oral route, octane m: <br /> hamoiagues. If it is as Y be more toxic than <br /> desch due pirated into the lungs, it t its lower <br /> to cardiac arrest, respiratory paralysis and as cause a rapid <br /> narcotic potency aE octane is approximately that of heptane b i . The <br /> does <br /> not exhibit the CNS effects seen witty hexane or heptattie, <br /> � In humans. <br /> due to the only reoorred eifeets are' blisreL'ng and burning <br /> Prolonged skin contact. <br /> !•.•• In animals, octane is a mucous membrane irritant. - <br /> concentrations, it caunies narcosis, It is expected Chat severe <br /> high <br /> exposure ir, humans uill produce the same effects. e <br /> vapor ley severe <br /> ofpex exposure. of 32,x00 ppm suffered respiratory arrest after exposed minco <br /> 4,.•� P Exposure to <br /> Of exposo P 12.840 ppm for 185 minutes caused a decreased <br /> seen after minu ee. s of expolowed by th 5350in 24 hours. <br /> + :�a narcosis was <br /> RPm (12.46.1938), <br /> Dodgy c� c,, <br /> Dodecane is not highly toxic. The lowest toxic dose for mice is <br /> 11 C'/kg when administered <br /> patantxacor of skin Percutaneously for 22 weeks. Dodecane is a <br /> CL threshold dose <br /> by benxo(a)pyrene, Tc decreased the <br /> phenyldodecane a dose by a factor of <br /> - applied toPicall.y to the LO. Dodecane rars and <br /> be''zestation 0 chrysene or benzo(b)triphenvleneyonfthe sev Created <br /> chwith <br /> Of gestation produced tumors in offspring, No additional inforn�txan <br /> - dav <br /> is available (12,1937) . <br /> en nS1r <br /> Isopencane is <br /> t r <br /> dizziness. headache. C:lS depressant. Effects may include exhilaration. <br /> do fine work oss of appetite, nausea, confusion, inability ca <br /> a persistent .asce of gasoline and in extreme cases, <br /> Of consciousness. Inhalation of up to 500 <br /> effect on humans, loss <br /> '�ery PPm appears to have -° <br /> the skin and eves. Repeated orprolongedpor concentrations <br /> cont ct Will dry <br /> irritating ;a <br /> daEac skin resulting i1 irritation and dermatitis. The <br /> mouse is estimated t° be and <br /> -- - 1000 mg/L {12) . <br /> 6157 <br />